SCHOOL OF CHEMICAL ENGINEERING AND TECHNOLOGY

德国马普煤炭研究所前所长——马尔堡大学教授报告2017.05.13

应天津大学合成生物学团队邀请,德国马普煤炭研究所前所长,马尔堡大学Manfred T. Reetz教授将于本周日(201757日)来访,并于上午10:3050222李绍芬报告厅做关于选择性酶定向进化的学术报告。欢迎感兴趣的老师同学参加。 


报告题目:Directed Evolution of Stereoselective Enzymes for Use in Organic Chemistry and Biotechnology


报告时间:201757日(周日)上午10:30


报告地点:北洋园校区50222李绍芬报告厅

报告人: Manfred T. Reetz教授(德国马普煤炭研究所前所长,马尔堡大学教授)


报告人简介:

Manfred T. Reetz is currently emeritus group leader of the Max-Planck-Institut für Kohlenforschung (MPI) in Mülheim/Germany and simultaneously Hans-Meerwein-Research-Professor at the University of Marburg/Germany, where he runs his current group. Previously he was Director at the MPI for two decades (1991-2011), and before that he held a chair for Organic Chemistry in Marburg (1980-1991).

Over the years Manfred T. Reetz has held many different offices and administrative positions, such as Chairman of the Chemistry Department at Marburg University, Director of the Max-Planck-Institut für Kohlenforschung, and Senator of the German National Academy of Sciences Leopoldina. He has also been a member of numerous boards, including Editorial Board of Angewandte Chemie and other journals such as Chemistry and Biology, Committee of the Fonds of the German Industrial Organization (FCI), and Committee of the prestigious Krupp-Foundation. He has also been and still is member of several important German, American and Israeli prize juries.

M. T. Reetz has published more than 560 peer-reviewed papers, a dozen book chapters and a book on organotitanium reagents. Another monograph on “Directed Evolution of Selective Enzymes” is due to appear in October 2016 (Wiley-VCH). He has authored 27 patents/applications. Reetz has been cited more than 38,000 times and has an h-index of 101 (Google).

As a chemist he developed numerous novel synthetic methods, reagents and catalysts for application in synthetic organic chemistry. The preparation of organotitanium reagents for chemo- and stereoselective C-C bond forming reactions is an early example, which at the time opened a whole new field, including Lewis acid mediated chelation controlled processes. Many other synthetic developments followed, including methods for the size-selective synthesis of nanostructured transition metal colloids, new applications of amino acids as chiral building blocks, and the use of economically viable chiral BINOL-derived monodentate phosphites as ligands in asymmetric transition metal catalyzed reactions. These and other highlights have enriched academic and industrial organic chemistry world wise.

The another notable achievement occurred in the area of biocatalysis during the last 20 years: The Reetz group pioneered the concept of directed evolution of stereo- and regioselective enzymes as efficient catalysts in organic chemistry and biotechnology. As a result, a new research field unfolded with the participation of many groups around the world, which led to the elimination of the long-standing limitations of enzymes. Today it constitutes a prolific source of catalysts for a wide variety of different asymmetric transformations, including enantioselective hydrolysis, oxidation, reduction, and C-C bond forming reactions. Ongoing methodology development in the Reetz group continues to enhance the efficacy of this protein engineering method.

 

Manfred T. Reetz教授是德国马普煤炭研究所前所长,马尔堡大学教授,近二十多年他一直从事酶的定向进化研究。现为德国《应用化学》(Angewandte Chemie)和化学生物学等多家学术杂志的编委,同时还是德国工业基础组织委员会(FCI)和著名的克虏伯基金会委员会的委员,并一直担任德国,美国和以色列等奖项陪审团成员。


Reetz教授已发表发表论文560多篇,专利27项和多篇论著被国内外同行引用达到超过38,000H-索引指数达101近期题为选择性酶定向进化的专著于201610(Wiley-VCH)刊发。


作为一名化学家,他开发了许多新的合成方法,多种试剂和催化剂在合成有机化学中得以应用。化疗有机金属钛试剂的准备和立体选择碳-碳键形成反应是一个早期的成就,当时打开了一个全新的领域,包括路易斯酸螯合受控过程介导的。许多其他的合成进展,包括size-selective方法合成纳米过渡金属胶体,氨基酸手性的新的应用程序构建块,和在不对称过渡金属催化反应使用经济上可行的手性BINOL-derived单原子螯合配体


20年里在生物催化领域:Reetz团队也取得了显著的成就,开创了特定选择性酶定向进化的概念,在此基础上将高效生物酶催化剂应用于有机化学和生物技术领域。并与世界各地的许多研究机构合作展开一个新的研究领域消除长期存在的酶应用方面的局限性。生产出多种来源的催化剂用于各种不对称转化反应,包括对映选择性水解、氧化、还原、和碳碳键形成。Reetz团队在该领域方法学的的持续开发将进一步加强蛋白质工程的效果。