SCHOOL OF CHEMICAL ENGINEERING AND TECHNOLOGY
Development of inorganic nanoparticles for cancer therapy and diagnosis2017.08.22报告题目：Development of inorganic nanoparticles for cancer therapy and diagnosis
报告人： Prof. Zhi Ping (Gordon) Xu，澳大利亚昆士兰大学
In this talk, I will first introduce two types of inorganic nanoparticles, i.e. layered double hydroxide (LDH) and lipid-coated calcium phosphate (LCP) nanoparticles, and then demonstrate their high potential as the drug/gene delivery vehicle. I will present a few examples to show efficient co-delivery of functional small interfering RNA (siRNA) and anti-cancer drug to cancer cells for the synergic inhibition. I will also talk about our recent results for target delivery to treat cancers.
In the second part, I will present our recent research using clay nanoparticles as vaccine adjuvants to promote higher and long-term immune responses against cancer and bacteria. We have noted that LDH is able to readily load model antigen ovalbumin (OVA) and the toll-like receptor ligand CpG together, promote higher levels of specific antibodies, and modulate the immune response from Th2 bias towards the preferred polarity Th1 for anti-cancer purpose. We have found that LDH and hectorite (HEC) nanoparticles as adjuvants to promote stronger and long-lasting immune responses against the infectious bacteria.
In the final part, I will demonstrate the capability of inorganic nanoparticles as positron emission tomography (PET) and magnetic resonance imaging (MRI) contrast agents for cancer imaging and detection.