SCHOOL OF CHEMICAL ENGINEERING AND TECHNOLOGY

【学术报告】Directed evolution of tools for drug discovery2016.12.08

报告题目:Directed evolution of tools for drug discovery
报 告 人:Andrew Ellington教授
报告时间:2016年12月14日上午9:30
报告地点:天津大学北洋校区50楼谢克昌报告厅
报告摘要:
The discovery of actionable drug targets and the biosynthesis of novel pharmacophores are interrelated challenges.  These challenges can be brought together by focusing on the functional identification of molecules that can activate or inhibit particular receptor classes.  Synthetic biology tool kits are a starting point for functional screens and selections based on tightly regulated feedback cascades.
报告人介绍:
1988 Ph.D. Biochemistry and Molecular Biology, Harvard University, Cambridge, MA
ACADEMIC APPOINTMENTS
1988 – 1991 Research Fellow, Department of Genetics, Harvard Medical School and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA
1992 – 1998 Associate Professor, Department of Chemistry, Indiana University, Bloomington, IN
1992 – 1998 Fellow, Institute for Molecular and Cellular Biology, Indiana University, Bloomington, IN
1998 – 2001 Associate Professor, Department of Chemistry/Biochemistry, University of Texas at Austin, Austin, TX
2001 – Present  Professor, Department of Chemistry/Biochemistry, University of Texas at Austin, Austin, TX
2001 – Present Adjunct Professor, Department of Carcinogenesis, M.D. Anderson Cancer Research Center
2006 – 2008  Adjunct Professor, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
HONORS AND AWARDS
1981 – 1984 NSF Fellowship
1993 Office of Naval Research Young Investigator Award
1994 American Foundation of AIDS Research Scholar Award
1994 NSF Young Investigator Award
1994 Pew Scholar in the Biomedical Sciences
1995 Cottrell Scholar Award
1995 – 1996 Outstanding Junior Faculty Award, Indiana University
1996 Camille Dreyfus Teacher-Scholar Award
1997 Indiana University Stonebelt Center Award
2001 – Present Wilson M. and Kathryn M. Fraser Scholar
2001 – Present Fellow, Institute for Cellular & Molecular Biology, The University of Texas at Austin
2006 Finalist (Top Five) for the Foresight Institute Feynman Prize
2006 – 2007  Intellectual Property Committee, Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX
2007 – Present Member of the Scientific Review Committee for the Catalyst for Innovation Leadership Council, and the Drug Discovery Core Steering Committee as part of the Clinical Translational Science Award
2007 – Present Member of International Advisory Board for Wiley Interdisciplinary Reviews: Nanomedicine
2007 – Present External Associate, Vanderbilt Institute of Integrative Biosystems Research and Education (VIIBRE), Vanderbilt University, Nashville, Tennessee
2007 – Present Member of the Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin
2010 National Security Science & Engineering Faculty Fellowship (NSSEFF)
2011 Photograph “Hello World” featured in “Talk to Me” exhibition, Museum of Modern Art, New York NY
2011-2012 President of the International Society for Nanoscale Science, Computation and Engineering
2012 – Present American Association for the Advancement of Science (AAAS) Fellow
2013 President's Associates Teaching Excellence Award, University of Texas
2014 National Academy of Sciences (NAS) Panel Member
2014 American Academy of Microbiology (AAM) Fellowship
2014 SRI International
2015 SRI International
2015 National Academy of Sciences (NAS) Panel Member
2015 University of Texas at Austin, Teaching Excellence Award
The Ellington Lab is attempting to develop novel synthetic organisms based on altering the translation apparatus and developing modular nucleic acid software. Translation engineering centers on the introduction of novel amino acids into proteins that have the capability to base-pair and is being pursued using a variety of techniques, including directed evolution, computational design, and high-throughput synthesis.