应天津大学合成生物学团队邀请,德国马普煤炭研究所前所长,马尔堡大学Manfred T. Reetz教授将于本周日(201757日)来访,并于上午10:3050222李绍芬报告厅做关于选择性酶定向进化的学术报告。欢迎感兴趣的老师同学参加。 

报告题目:Directed Evolution of Stereoselective Enzymes for Use in Organic Chemistry and Biotechnology



报告人: Manfred T. Reetz教授(德国马普煤炭研究所前所长,马尔堡大学教授)


Manfred T. Reetz is currently emeritus group leader of the Max-Planck-Institut für Kohlenforschung (MPI) in Mülheim/Germany and simultaneously Hans-Meerwein-Research-Professor at the University of Marburg/Germany, where he runs his current group. Previously he was Director at the MPI for two decades (1991-2011), and before that he held a chair for Organic Chemistry in Marburg (1980-1991).

Over the years Manfred T. Reetz has held many different offices and administrative positions, such as Chairman of the Chemistry Department at Marburg University, Director of the Max-Planck-Institut für Kohlenforschung, and Senator of the German National Academy of Sciences Leopoldina. He has also been a member of numerous boards, including Editorial Board of Angewandte Chemie and other journals such as Chemistry and Biology, Committee of the Fonds of the German Industrial Organization (FCI), and Committee of the prestigious Krupp-Foundation. He has also been and still is member of several important German, American and Israeli prize juries.

M. T. Reetz has published more than 560 peer-reviewed papers, a dozen book chapters and a book on organotitanium reagents. Another monograph on “Directed Evolution of Selective Enzymes” is due to appear in October 2016 (Wiley-VCH). He has authored 27 patents/applications. Reetz has been cited more than 38,000 times and has an h-index of 101 (Google).

As a chemist he developed numerous novel synthetic methods, reagents and catalysts for application in synthetic organic chemistry. The preparation of organotitanium reagents for chemo- and stereoselective C-C bond forming reactions is an early example, which at the time opened a whole new field, including Lewis acid mediated chelation controlled processes. Many other synthetic developments followed, including methods for the size-selective synthesis of nanostructured transition metal colloids, new applications of amino acids as chiral building blocks, and the use of economically viable chiral BINOL-derived monodentate phosphites as ligands in asymmetric transition metal catalyzed reactions. These and other highlights have enriched academic and industrial organic chemistry world wise.

The another notable achievement occurred in the area of biocatalysis during the last 20 years: The Reetz group pioneered the concept of directed evolution of stereo- and regioselective enzymes as efficient catalysts in organic chemistry and biotechnology. As a result, a new research field unfolded with the participation of many groups around the world, which led to the elimination of the long-standing limitations of enzymes. Today it constitutes a prolific source of catalysts for a wide variety of different asymmetric transformations, including enantioselective hydrolysis, oxidation, reduction, and C-C bond forming reactions. Ongoing methodology development in the Reetz group continues to enhance the efficacy of this protein engineering method.


Manfred T. Reetz教授是德国马普煤炭研究所前所长,马尔堡大学教授,近二十多年他一直从事酶的定向进化研究。现为德国《应用化学》(Angewandte Chemie)和化学生物学等多家学术杂志的编委,同时还是德国工业基础组织委员会(FCI)和著名的克虏伯基金会委员会的委员,并一直担任德国,美国和以色列等奖项陪审团成员。