Development of inorganic nanoparticles for cancer therapy and diagnosis2017.08.22

报告题目:Development of inorganic nanoparticles for cancer therapy and diagnosis
报告人:  Prof. Zhi Ping (Gordon) Xu,澳大利亚昆士兰大学
报告时间:2017年9月3日 (周日)09:30-11:00
In this talk, I will first introduce two types of inorganic nanoparticles, i.e. layered double hydroxide (LDH) and lipid-coated calcium phosphate (LCP) nanoparticles, and then demonstrate their high potential as the drug/gene delivery vehicle. I will present a few examples to show efficient co-delivery of functional small interfering RNA (siRNA) and anti-cancer drug to cancer cells for the synergic inhibition. I will also talk about our recent results for target delivery to treat cancers.
In the second part, I will present our recent research using clay nanoparticles as vaccine adjuvants to promote higher and long-term immune responses against cancer and bacteria. We have noted that LDH is able to readily load model antigen ovalbumin (OVA) and the toll-like receptor ligand CpG together, promote higher levels of specific antibodies, and modulate the immune response from Th2 bias towards the preferred polarity Th1 for anti-cancer purpose. We have found that LDH and hectorite (HEC) nanoparticles as adjuvants to promote stronger and long-lasting immune responses against the infectious bacteria.
In the final part, I will demonstrate the capability of inorganic nanoparticles as positron emission tomography (PET) and magnetic resonance imaging (MRI) contrast agents for cancer imaging and detection.