黄　鹤

现任职称/职务：教授，博士生导师
通讯地址：天津大学北洋园校区54E315
电子邮箱：huang@tju.edu.cn
办公电话：

论著专利:

近年代表性论文:                 

Please refer to  https://orcid.org/0000-0003-3008-4869.

2015

Min Li, Xiaodan Fan, Jing Liu, Yaozhong Hu and He Huang. Selection by phage display of Nanobodies directed against Hypoxia Inducible Factor-1a (HIF-1a). Biotechnology and Applied Biochemistry (accepted,DOI: 10.1002/bab.1340)

Haoying Dou, Nan Yang, Yuanyuan Wang, Mingli Heng, Xuan Zhou, Huaien Bu, Fang Xu, Tieniu Zhao, He Huang and Hongwu Wang. The association between genetic variants and characteristic symptoms of type 2 diabetes: A matched case-control study. Chinese Journal of Integrative Medicine(accepted)

Haoran Yu; Yang Zhao; Chao Guo; YiruGan; He Huang. The Role of Proline Substitutions within Flexible Regions on Thermostability of Luciferase. BBA - Proteins and Proteomics 1854 (1)：65-72.

2014

Zhang Wenyong, Wang Damei, Gan Yiru, Huang He. Fusion Expression of Human Trpsin with DsbA in E. coli.Chemical Industry and Engineering31(6): 75-79. (in Chinese)

Huang, He; Dong, Yan; Yang, Zhi-Liang; Luo, Hao; Zhang, Xi; Gao, Feng. Complete genome sequence of pABTJ2, a new plasmid from Acinetobacterbaumannii MDR-TJ carrying many phage-like elements.Genomics, Proteomics & Bioinformatics 12(4): 172-177.

Xiao Zhao, Song Gao, He Ren, He Huang, Wei Ji, JihuiHao. Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models. Current Molecular Medicine 14 (4): 555-63.

Xiaodan Fan, Yaozhong Hu, He Huang. Nanobodies: Novel biomedical vehicles in targeting tumor. Journal of Chemical and Pharmaceutical Research 6(3): 458-462. 

Hao-RanYu, He Huang. Engineering Proteins for Thermostability throughRigidifying Flexible Sites (RFS). JBA 32: 308–315.

2013

Yu Haoran, Liu Yanjie, HuoLiujie, Liang Xinya,Kang Guangbo and Huang He. Soluble Expression of Active RecombinantFirefly Luciferase in Escherichia coli. JOURNAL OF PURE AND APPLIED MICROBIOLOGY 7: 679-685.

Duan Yitao, Zhao Hui, Huang He. Research progress on endogenous and exogenous ligands of aryl hydrocarbon receptor. Journal of Environment and Health 30(5): 456-458. (in Chinese)

LIU Jing, HU Yao-zhong, HUANG He. Research Progress of Nanobodies in Diagnosis and Therapy of Tumer. Chemical Industry and Engineering 30(4)：29-35. (in Chinese)

Li T, Ma SY, Tang XC, Nie LY, Huang H. Production and characterization of highly purified recombinant thymosin beta 4 in Escherichia coli. Protein expression and purification 90: 90-5.

Zhe Wang, He Huang. Platelet factor-4 (CXCL4/PF-4): An Angiostatic Chemokine for Cancer Therapy. Cancer Letters 331: 147–153.

Yaozhong Hu, Jing Liu, He Huang. Recent agents targeting HIF-1α for cancer therapy. J CELL BIOCHEM 114(3): 498-509.

He Huang, Jing Liu,YingjinFeng,Weiru Chen. The distribution of apoliprotein E gene polymorphism in Chinese civil aircrews, and a possible risk factor to their overweight and dyslipidemia is cumulative flight time. Clinica Chimica Acta 416(1): 36-40.

2012

Jing Liu, Yaozhong Hu, He Huang. Nanobodies: novel biomedical vehicle to battle tumor, International Conference on Bioinformatics and Biomedical Engineering, 4: 95-98, Shanghai, 2012, Conference Report

HeHuang, Zhi-Liang Yang, Xiao-MengWu, Yue Wang, Yan-Jie Liu, HaoLuo, XingLv, Yi-RuGan, Shi-DuoSong, FengGao. Complete genome sequence of Acinetobacterbaumannii MDR-TJ and insights into its mechanism of antibiotic resistance. JAC 67(12): 2825-2832.

Yitao Duan, Zhe Wang, Wei Wu, Zhenjiang Fang, HeHuang. Polycistronic expression of human platelet factor 4 with heparin-neutralizing activity in Escherichia coli.Bioscience, Biotechnology, and Biochemistry 76(10): 1855-1860.

Yuhang Cai, He Huang. Advances in the study of protein-DNA interaction. AMAC 43: 1141–1146.

Mei-Ning Xing, Xue-Zhu Zhang, He Huang. Application of metagenomic technique in mining enzymes from microbial communities for biofuel synthesis. JBA 30: 920-9.

2011

Wang XC, Liu YW, Ren H, Yuan ZH, Li SS, Sheng J, Zhao TS, Chen Y, Liu FH, Wang F, Huang H,HaoJH. Polymorphisms in the hypoxia-inducible factor-1 alpha gene confer susceptibility to pancreatic cancer. Cancer Biology & Therapy 12: 383-7.

XiuchaoWANG, Zhanna YUAN, Shasha LI, Jun SHENG, Tiansuo ZHAO, Song GAO, He REN, He HUANG, Jihui HAO. Expression of Hypoxia-Inducible Factor-2α in Hepatocellular Carcinoma and Its Clinical Significance. Chinese Journal of Clinical Oncology 38（10）：560-563. (in Chinese)

Gao F, Wang Y, Liu YJ, Wu XM, Lv X, Gan YR, Song SD, Huang H. Genome sequence of Acinetobacter baumannii MDR-TJ. Journal of bacteriology 193: 2365-6.

Feng J, Zhao Y, Yang X, Zhao H, Huang H. Synthesis of 20nm colloidal gold by microwave heating method. Advanced Materials Research 2011; 204-210: 2045-8.

第一发明人授权专利：

ZL201210465441.X 针对乏氧诱导因子-1a的纳米抗体及其编码序列

ZL201310293868.0 一种萤火虫荧光素酶及其编码基因及获取方法

ZL201310318276.X 靶向性重组PF4及其表达系统

ZL201520121594.1 乳腺癌早期预报家庭三联卡胶体金试剂盒

ZL201510665921.4 一种突变型Sus scrofa猪源胰蛋白酶及其编码基因及获取方法和应用

ZL201510176123.5 靶向性重组PF4及其表达系统

合著:

《实用病毒学》，天津科技翻译出版公司1999年12月出版。

《现代糖尿病学》，天津科学技术出版社2000年7月出版。

《生物化学》，高等教育出版社2010年2月出版。