吴　毅

现任职称/职务：英才教授/博导
通讯地址：天津大学北洋园校区54楼E213
电子邮箱：yi.wu@tju.edu.cn
办公电话：

论著专利:

1.       Ma, Y., Su, S., Fu, Z., Zhou, C., Qiao, B., Wu, Y.*, & Yuan, Y. J*. (2024). Convenient synthesis and delivery of a megabase-scale designer accessory chromosome empower biosynthetic capacity. Cell Research, 1-14.

2.     Xu, H., Han, M., Zhou, S., Li, B. Z., Wu, Y.*, & Yuan, Y. J. (2020). Chromosome drives via CRISPR-Cas9 in yeast. Nature communications, 11(1), 4344.

3.     He, B., Ma, Y., Tian, F., Zhao, G. R., Wu, Y.*, & Yuan, Y. J*. (2023). YLC-assembly: large DNA assembly via yeast life cycle. Nucleic Acids Research, 51(15), 8283-8292.

4.     Fu, Z. H., He, S. Z., Wu, Y.*, & Zhao, G. R*. (2023). Design and deep learning of synthetic B-cell-specific promoters. Nucleic Acids Research, 51(21), 11967-11979.

5.     Zhou, S.#, Wu, Y.#, Zhao, Y.#, Zhang, Z., Jiang, L., Liu, L., Zhang, Y., Tang, J., & Yuan, Y. J*. (2023). Dynamics of synthetic yeast chromosome evolution shaped by hierarchical chromatin organization. National science review, 10(5), nwad073.

6.     Xiong, Y., Zhang, H., Zhou, S., Ma, L., Xiao, W., Wu, Y.*, & Yuan, Y. J. (2023). Structural Variations and Adaptations of Synthetic Chromosome Ends Driven by SCRaMbLE in Haploid and Diploid Yeasts. ACS synthetic biology, 12(3), 689–699.

7.     Guo, Z., Yin, H., Ma, L., Li, J., Ma, J., Wu, Y.*, & Yuan, Y. (2022). Direct Transfer and Consolidation of Synthetic Yeast Chromosomes by Abortive Mating and Chromosome Elimination. ACS synthetic biology, 11(10), 3264–3272.

8.  Kang, J., Li, J., Guo, Z., Zhou, S., Su, S., Xiao, W., Wu, Y.*, & Yuan, Y. (2022). Enhancement and mapping of tolerance to salt stress and 5-fluorocytosine in synthetic yeast strains via SCRaMbLE. Synthetic and systems biotechnology, 7(3), 869–877.

9.  Zhou, S.#, Wu, Y.#, Xie, Z. X., Jia, B., & Yuan, Y. J*. (2021). Directed genome evolution driven by structural rearrangement techniques. Chemical Society reviews, 50(22), 12788–12807.

10.  Han, P., Ma, Y., Fu, Z., Guo, Z., Xie, J., Wu, Y.*, & Yuan, Y. J. (2021). A DNA Inversion System in Eukaryotes Established via Laboratory Evolution. ACS synthetic biology, 10(9), 2222–2230.

11.  Wang, P., Xu, H., Li, H., Chen, H., Zhou, S., Tian, F., Li, B. Z., Bo, X., Wu, Y.*, & Yuan, Y. J. (2020). SCRaMbLEing of a Synthetic Yeast Chromosome with Clustered Essential Genes Reveals Synthetic Lethal Interactions. ACS synthetic biology, 9(5), 1181–1189.

12.  Ma, L., Li, Y., Chen, X., Ding, M., Wu, Y.*, & Yuan, Y. J. (2019). SCRaMbLE generates evolved yeasts with increased alkali tolerance. Microbial cell factories, 18(1), 52.

13.  Li, Y.#, Wu, Y.#, Ma, L., Guo, Z., Xiao, W., & Yuan, Y*. (2019). Loss of heterozygosity by SCRaMbLEing. Science China. Life sciences, 62(3), 381–393.

14.  Wu, Y.#, Zhu, R. Y.#, Mitchell, L. A., Ma, L., Liu, R., Zhao, M., Jia, B., Xu, H., Li, Y. X., Yang, Z. M., Ma, Y., Li, X., Liu, H., Liu, D., Xiao, W. H., Zhou, X., Li, B. Z., Yuan, Y. J., & Boeke, J. D*. (2018). In vitro DNA SCRaMbLE. Nature communications, 9(1), 1935.

15.  Shen, M. J.#, Wu, Y.#, Yang, K., Li, Y., Xu, H., Zhang, H., Li, B. Z., Li, X., Xiao, W. H., Zhou, X., Mitchell, L. A., Bader, J. S., Yuan, Y., & Boeke, J. D*. (2018). Heterozygous diploid and interspecies SCRaMbLEing. Nature communications, 9(1), 1934.

16.  Jia, B.#, Wu, Y.#, Li, B. Z.#, Mitchell, L. A., Liu, H., Pan, S., Wang, J., Zhang, H. R., Jia, N., Li, B., Shen, M., Xie, Z. X., Liu, D., Cao, Y. X., Li, X., Zhou, X., Qi, H., Boeke, J. D., & Yuan, Y. J*. (2018). Precise control of SCRaMbLE in synthetic haploid and diploid yeast. Nature communications, 9(1), 1933.

17.  Wu, Y.#, Li, B. Z.#, Zhao, M., Mitchell, L. A., Xie, Z. X., Lin, Q. H., Wang, X., Xiao, W. H., Wang, Y., Zhou, X., Liu, H., Li, X., Ding, M. Z., Liu, D., Zhang, L., Liu, B. L., Wu, X. L., Li, F. F., Dong, X. T., Jia, B., … Yuan, Y. J. (2017). Bug mapping and fitness testing of chemically synthesized chromosome X. Science, 355(6329), eaaf4706.