肖文海

现任职称/职务：副教授
通讯地址：天津市南开区卫津路92#
电子邮箱：wenhai.xiao@tju.edu.cn
办公电话：18002007081

论著专利:

1、Ajikumar PK, Xiao WH, Tyo KE, Wang Y, Simeon F, Leonard E, Mucha O, Phon TH, Pfeifer B, Stephanopoulos G*; Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli; Science; 330(6000); 2010;70-4

2、Santos CN, Xiao W, Stephanopoulos G*; Rational, combinatorial, and genomic approaches for engineering L-tyrosine production in Escherichia coli. Proc Natl Acad Sci U S A; 109(34); 2012; 13538-43

3、Leonard E, Ajikumar PK, Thayer K, Xiao WH, Mo JD, Tidor B, Stephanopoulos G, Prather KL*; Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control; Proc Natl Acad Sci U S A; 107(31); 2010; 13654-9

4、Chen, Y; Wang, Y; Liu, M; Qu, JZ; Yao, MD; Li, B; Ding, MZ; Liu, H; Xiao, WH*; Yuan, YJ. Primary and Secondary Metabolic Effects of a Key Gene Deletion (Delta YPL062W) in Metabolically Engineered Terpenoid-Producing Saccharomyces cerevisiae. Applied and Environment Microbiology. 2019, 85(7): UNSP e01990-18. WOS:000463406200004

5、Jin, J; Wang, Y; Yao, MD; Gu, XL; Li, B; Liu, H; Ding, MZ; Xiao, WH*; Yuan, YJ. Astaxanthin overproduction in yeast by strain engineering and new gene target uncovering. Biotechnology for Biofuels. 2018, 11: 230. WOS:000442556500002

6、Song, TQ; Ding, MZ; Zhai, F; Liu, D; Liu, H; Xiao, WH*; Yuan, YJ. Engineering Saccharomyces cerevisiae for geranylgeraniol overproduction by combinatorial design. Scientific Reports. 2017 7:14991. WOS:000414641900006

7、Zhang, Y; Wang, Y; Yao, MD; Liu, H; Zhou, X; Xiao, WH*; Yuan, YJ. Improved campesterol production in engineered Yarrowia lipolytica strains. Biotechnology Letters.

2017. 39(7):1033-1039. WOS:000402394300012.

8、 Xiong, ST; Wang, Y; Yao, MD; Liu, H; Zhou, X; Xiao, WH*; Yuan, YJ. Cell foundry with high product specificity and catalytic activity for 21-deoxycortisol biotransformation. Microbial Cell Factories. 2017. 16:105. WOS:000403304800001.

9、Jiang, GZ; Yao, MD; Wang, Y; Zhou, L; Song, TQ; Liu, H; Xiao, WH*; Yuan, YJ. Manipulation of GES and ERG20 for geraniol overproduction in Saccharomyces cerevisiae. Metabolic Engineering. 2017 41:57-66. WOS:000401696800006.

10、Chai, FH; Wang, Y; Mei, X; Yao, MD; Chen, Y; Liu, H; Xiao, WH; Yuan, YJ. Heterologous biosynthesis and manipulation of crocetin in Saccharomyces cerevisiae. Microbial Cell Factories. 2017 16:54. WOS:000397748400001.

11、Wang, RZ; Gu, XL ; Yao, MD; Pan, CH ; Liu, H; Xiao, WH*; Wang, Y*; Yuan, YJ. Engineering of beta-carotene hydroxylase and ketolase for astaxanthin overproduction in Saccharomyces cerevisiae. Frontier of Chemical Science and Engineering. 2017. 11(1):89-99. WOS:000398723700010.

12、Cao, YX; Xiao, WH# ; Zhang, JL; Xie, ZX ; Ding, MZ; Yuan, YJ. Heterologous biosynthesis and manipulation of alkanes in Escherichia coli. Metabolic Engineering. 2016 38:19-28. WOS:000387984600003.

13、      Chen, Y; Xiao, WH*; Wang, Y; Liu, H; Li, X; Yuan, YJ. Lycopene overproduction in Saccharomyces cerevisiae through combining pathway engineering with host engineering. Microbial Cell Factories. 2016 15:113. WOS:000378575600002.

14、      Du, HX; Xiao, WH#; Wang, Y# ; Zhou, X; Zhang, Y ; Liu, D; Yuan, YJ. Engineering Yarrowia lipolytica for Campesterol Overproduction. Plos One. 2016 11(1): e0146773. WOS:000367888100149

  15、Su, W ; Xiao, WH#; Wang, Y# ; Liu, D ; Zhou, X; Yuan, YJ. Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae Plos One 2015 10(6): e0130840. WOS:000356835800109