SCHOOL OF CHEMICAL ENGINEERING

教师登录系统

工号:

密码:

验证:

查询:

副教授

陈 磊

现任职称/职务:制药工程系副教授/博导
通讯地址:天津市南开区卫津路92号天津大学化工学院
电子邮箱:lchen@tju.edu.cn
办公电话:022-27406364

论著专利:

(1)    Pei, G., Li, X., Liu, L., Liu, J., Wang, F., Chen, L., Zhang W. De novo transcriptomic and metabolomic analysis of docosahexaenoic acid (DHA) - producing Crypthecodinium cohnii during fed-batch fermentation. Algal Research 2017, Accepted.

(2)    Sun, T., Xu, L., Wu, L., Song, Z., Chen, L.*, Zhang, W. Identification of a new target slr0946 of the response regulator Sll0649 involving cadmium tolerance in Synechocystis sp. PCC 6803. Frontiers in Microbiology 2017, Accepted. doi: 10.3389/fmicb.2017.01582

(3)    Chen, Z., Chen, L.*, Zhang, W. Tools for genomic and transcriptomic analysis of microbes at single-cell level. Frontiers in Microbiology 2017, In review. (IF=4.165, 二区)

(4)    Liu, J, Pei, G., Diao, J., Chen, Z., Liu, L., Chen, L., Zhang, W. Screening and transcriptomic analysis of Crypthecodinium cohnii mutants with high growth and lipid content using the acetyl-CoA carboxylase inhibitor sethoxydim. Applied Microbiology and Biotechnology 2017, 101(15), 6179-6191. (IF=3.376, 二区)

(5)    Sun, T., Chen, L.*, Zhang, W. Quantitative proteomics reveals potential crosstalk between a small RNA CoaR and a two-component regulator Slr1037 in Synechocystis sp. PCC6803. Journal of Proteome Research 2017, 16(8):2954-2963. (IF=4.173, 二区)

(6)    Gao, X., Sun, T., Wu, L., Chen, L.*, Zhang, W. Co-overexpression of response regulator genes slr1037 and sll0039 improves tolerance of Synechocystis sp. PCC 6803 to 1-butanol. Bioresource Technology 2017, doi: 10.1016/j.biortech.2017.04.112.

(7)    王康,刘良森,陈磊*,张卫文。使用稀禾定驯化提高裂殖壶菌的生长和DHA积累。食品与发酵工业 2017, 43(7),42-48.  DOI:10.13995/j.cnki.11-1802/ts.014107

(8)     Pei, G., Niu, X., Zhou, Y., Chen, L.*, Zhang, W. Crosstalk of two-component signal transduction systems in regulating central carbohydrate and energy metabolism during autotrophic and photomixotrophic growth of Synechocystis sp. PCC 6803. Integrative Biology 2017, 9(5):485-496. (IF=3.371, 二区)

(9)    陈子熙,陈磊,张卫文。单细胞尺度下的微生物学研究:意义与方法。微生物学报 2017,57(6):920-931.

(10)Li, X., Pei, G., Liu, L., Chen, L.*, Zhang, W. Metabolomic analysis and lipid accumulation in a glucose tolerant Crypthecodinium cohnii strain obtained by adaptive laboratory evolution. Bioresource Technology 2017, 235:87-95. (IF=4.917, 一区) (封面文章

(11)Pei, G., Sun, T., Chen, S., Chen, L., Zhang, W. Systematic and functional identification of small non-coding RNAs associated with exogenous biofuel stress in cyanobacterium Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2017, 10:57. (IF=6.444, 一区)

(12) Shi, M., Zhang, X., Pei, G., Chen, L.*, Zhang, W. Functional diversity of transcriptional regulators in the cyanobacterium Synechocystis sp. PCC 6803. Frontiers in Microbiology 2017, 8:280. (IF=4.165, 二区)

(13) Sun, T., Pei, G., Wang, J., Chen, L.*, Zhang, W.* A novel small RNA CoaR regulates coenzyme A biosynthesis and tolerance of Synechocystis sp. PCC6803 to 1-butanol possibly via promoter-directed transcriptional silencing. Biotechnology for Biofuels 2017, 10:42. (IF=6.444, 一区)

(14) 孙韬,陈磊*,张卫文。应用合成生物学策略改良光合蓝细菌。生物产业技术,2017, 01:58-63.

(15) Xie, M., Wang, W., Zhang, W., Chen, L., Lu, X. Versatility of hydrocarbon production in cyanobacteria. Applied Microbiology and Biotechnology 2016, 101(3): 905-919. (IF=3.376, 二区)

(16)Wang, Y., Chen, L.*, Zhang, W*. Proteomic and metabolomic analyses reveal metabolic responses to 3-hydroxypropionic acid synthesized internally in cyanobacterium Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2016, 9:209. (IF=6.444, 一区)

(17) Khan, RI, Wang, Y., Afrin, S., Wang, B., Liu, Y., Zhang, X., Chen, L., Zhang, W., He, L., Ma, G. Transcriptional regulator PrqR plays a negative role in glucose metabolism and oxidative stress acclimation in Synechocystis sp. PCC 6803. Scientific Reports 2016, 6:32507. (IF=5.228, 二区)

(18) Sun, T. Chen, L., Zhang, W. Microbial production of mammalian melatonin - a promising solution to melatonin industry. Biotechnology Journal. 2016, 11(5):601-602. (IF=3.781, 二区)

(19) Chen, S., Zheng, G., Zhu, H., He, H., Chen, L., Zhang, W., Jiang, W., Lu, Y. Roles of two-component system AfsQ1/Q2 in regulating biosynthesis of the yellow-pigmented coelimycin P2 in Streptomyces coelicolor. FEMS Microbiology Letters 2016, 363(15). (IF=1.858, 四区)

(20) Xue, Q., Yang, Y., Chen, J., Chen, L., Yang, S., Jiang, W., Gu, Y. Roles of three AbrBs in regulating two-phase Clostridium acetobutylicum fermention. Applied Microbiology and Biotechnology 2016, 100(21):9081-9089. (IF=3.376, 二区)

(21) Fu, Y., Chen, L.*, Zhang, W. Regulatory mechanisms related to biofuel tolerance in producing microbes. Journal of Applied Microbiology 2016, 121(2):320-332. (IF=2.156, 三区)

(22) Zhang, Y., Pei, G., Chen, L.*, Zhang, W.* Metabolic dynamics of Desulfovibrio vulgaris biofilm grown on steel surface. Biofouling, 2016, 32(7):725-736. (IF=3.000, 三区)

(23) Li, T., Zhang, Y., Shi, M., Pei, G. Chen, L.*, Zhang, W.* A putative magnesium transporter Slr1216 involved in sodium tolerance in cyanobacterium Synechocystis sp. PCC 6803. Algal Research, 2016, 17: 202-210. (IF=4.694, 二区)

(24) Zou, X., Pan, T., Chen, L., Tian, Y., Zhang, W. Luminescence materials for pH and oxygen sensing in microbial cells - structures, optical properties, and biological applications. Critical Reviews In Biotechnology 2016, 37(6):723-738. (IF=7.510, 一区)

(25) Qi, Z., Chen, L., Zhang, W. Comparison of Transcriptional Heterogeneity of Eight Genes between Batch Desulfovibrio vulgaris Biofilm and Planktonic Culture at a Single-Cell Level. Frontiers in Microbiology 2016, 7: 597. (IF=4.165, 二区)

(26) Ge, X., Yu, Y., Zhang, M., Chen, L., Chen, W., Elrami, F., Kong, F., Kitten, T., Xu, P. Involvement of NADH Oxidase in Competition and Endocarditis Virulence in Streptococcus sanguinis. Infection and Immunity 2016, 84(5):1470-1477. (IF=3.603, 二区)

(27) Gao, X., Sun, T., Pei, G., Chen, L.*, Zhang, W. Cyanobacterial chassis engineering for enhancing production of biofuels and chemicals. Applied Microbiology and Biotechnology 2016, 100(8), 3401-3413. (IF=3.376, 二区)

(28) Wang,Y., Sun, T., Gao, X., Shi, M., Wu, L., Chen, L., Zhang, W. Biosynthesis of platform chemical 3-hydroxypropionic acid (3-HP) directly from CO2 in cyanobacterium Synechocystis sp. PCC 6803. Metabolic Engineering 2016, 34:60-70. (IF=8.201, 一区)

(29) Wang, J., Chen, L., Chen, Z., Zhang, W. RNA-seq based transcriptomic analysis of single bacterial cells. Integrative Biology, 2015, 7, 1466 - 1476. (IF=3.371, 二区)

(30) Yu, X., Niu, X., Zhang, X., Pei, G., Liu, J., Chen, L.*, Zhang, W. *Identification and mechanism analysis of chemical modulators enhancing astaxanthin acc umulation in Haematococcus pluvialis. Algal Research 2015, 11:284-293. (IF=4.694, 二区)

(31) Gao, L., Pei, G., Chen, L., Zhang, W. A global network-based protocol for functional inference of hypothetical proteins in Synechocystis sp. PCC 6803. Journal of Microbiological Methods 2015, 116:44-52. (IF=1.857, 四区)

(32) Zhang, Y., Niu, X., Shi, M., Pei, G., Zhang, X., Chen, L.*, Zhang, W.* Identification of a transporter Slr0982 involved in ethanol tolerance in cyanobacterium Synechocystis sp. PCC 6803   . Frontiers in Microbiology 2015, 6:487. (IF=4.165, 二区)

(33) Li, J., Niu, X., Pei, G., Sui, X., Zhang, X., Chen, L., Zhang, W. Identification and metabolomic analysis of chemical modulators for lipid accumulation in Crypthecodinium cohnii. Bioresource Technology 2015, 191:362-368. (IF=4.917, 一区)

(34) 徐乐,巫琴,晋虎,陈磊*,张卫文。集胞藻PCC 6803中脂肪酸激活酶Slr1609互作蛋白的鉴定分析。生物工程学报 2015, 31(8): 1194−1202.

(35) 牛向凤,张晓清,于馨恒,苏营雪,陈磊,张卫文。液相质谱联用的代谢组方法优化及其在蓝细菌分析中的应用。生物工程学报 2015,31(4):577-590.

(36) Yu, X., Chen, L., Zhang, W. Chemicals to enhance microalgal growth and accumulation of high-value bioproducts. Frontiers in Microbiology 2015, 6:56. (IF=4.165, 二区)

(37) Niu, X., Zhu, Y., Pei, G., Wu, L., Chen, L.*, Zhang, W.* Elucidating butanol tolerance mediated by a response regulator Sll0039 in Synechocystis sp. PCC 6803 using a metabolomic approach. Applied Microbiology and Biotechnology 2015, 99(4):1845-1857. (IF=3.376, 二区)

(38) Zhu, Y., Pei, G., Niu, X., Shi, M., Zhang, M., Chen, L.*, Zhang, W*. Metabolomic analysis reveals functional overlapping of three signal transduction proteins in regulating ethanol tolerance in Synechocystis sp. PCC 6803. Molecular Biosystems 2015, 11(3):770-782. (IF=2.829, 三区)   

(39) Qi, Z., Pei, G., Chen, L., Zhang, W. Single-cell analysis reveals gene-expression heterogeneity in syntrophic dual-culture of Desulfovibrio vulgaris with Methanosarcina barkeri. Scientific Reports 2014, 4:7478. (IF=5.228, 二区)

(40) Sui, X., Niu, X., Shi, M., Li, J., Pei, G., Chen, L., Wang, J., Zhang, W. Metabolomic analysis reveals mechanism of antioxidant butylated hydroxyaniaole on lipid accumulation in Crypthecodinium cohnii.   Journal of Agricultural and Food Chemistry 2014, 62(51):12477-12484. (IF=2.857, 一区)

(41) Pei, G., Chen, L., Wang, J., Qiao, J., Zhang, W. Protein network signatures associated with exogenous biofuels treatments in cyanobacterium Synechocystis sp. PCC 6803. Frontiers in Bioengineering and Biotechnology 2014, 2:48.

(42) Wang, Y., Shi, M., Niu, X., Zhang, X., Gao, L., Chen, L., Wang, J. Zhang, W. Metabolomic basis of laboratory evolution of butanol tolerance in photosynthetic Synechocystis sp. PCC 6803. Microbial Cell Factories 2014, 13(1):151. (IF=3.744, 二区)

(43) Song, Z., Chen, L.*, Wang, J., Lu, Y., Jiang, W., Zhang, W.* A transcriptional regulator Sll0794 regulates tolerance to biofuel ethanol in photosynthetic Synechocystis sp. PCC 6803. Molecular & Cellular Proteomics 2014, 13(12):3519-3532. (IF=5.912, 二区)

(44) Su, Y., Wang, J., Shi, M., Niu, X., Yu, X., Gao, L., Zhang, X., Chen, L., Zhang, W. Metabolomic and network analysis of astaxanthin-producing Haematococcus pluvialis under various stress conditions. Bioresource Technology 2014, 170:522-529. (IF=4.917, 一区)

(45) Ren, Q., Shi, M., Chen, L.*, Wang, J., Zhang, W. * Integrated proteomic and metabolomic characterization of a novel two-component response regulator Slr1909 involved in acid tolerance in Synechocystis sp. PCC 6803. Journal of Proteomics 2014, 109C:76-89. (IF=3.867, 二区)

(46) Chen, L., Wu L., Wang, J., Zhang, W. Butanol tolerance regulated by a two-component response regulator Slr1037 in photosynthetic Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2014, 7:89. (IF=6.444, 一区)

(47) Chen, L., Wu, L., Zhu, Y., Song, Z., Wang, J., Zhang, W. An orphan two-component response regulator Slr1588 involves salt tolerance by directly regulating synthesis of compatible solutes in photosynthetic Synechocystis sp. PCC 6803. Molecular Biosystems 2014, 10(7):1765-1774. (IF=2.829, 三区)

(48) Chen, L., Zhu, Y., Song, Z., Wang, J., Zhang, W. An orphan response regulator Sll0649 involved in cadmium tolerance and metal homeostasis in photosynthetic Synechocystis sp. PCC 6803. Journal of Proteomics 2014, 103:87-102. (IF=3.867, 二区)

(49) Wang, J., Zhang, X., Shi, M., Gao, L., Niu, X., Te, R., Chen, L., Zhang, W. Metabolomic analysis of the salt-sensitive mutants reveals changes in amino acid and fatty acid composition important to long-term salt stress in Synechocystis sp. PCC 6803. Functional & Integrative Genomics 2014, 14(2):431-440. (IF=2.265, 二区)

(50) Jin, H., Chen, L., Wang, J., Zhang, W. Engineering biofuel tolerance in non-native producing microorganisms. Biotechnology Advances 2014, 32(2):541-548. (IF=9.848, 一区)

(51) Evans, K., Stone, V., Chen, L., Ge, X., Xu, P. Systematic study of genes influencing cellular chain length in Streptococcus sanguinis. Microbiology 2014, 160(Pt 2):307-315. (IF=2.268, 三区)

(52) 任蔷,陈磊,王江新,张卫文。应用合成生物学构建蓝细菌细胞工厂的研究进展。生命科学 2013, 25(10): 952-957。

(53) Wang, J., Chen, L., Tian, X., Gao, L., Niu, X., Shi, M., Zhang, W. Global metabolomic and network analysis of Escherichia coli responses to biofuel stresses. Journal of Proteome Research 2013, 12: 5302−5312. (IF=4.173, 二区)

(54) Zhu, H., Ren, X., Wang, J., Song, Z., Shi, M., Qiao, J., Tian, X., Liu, J., Chen, L.*, Zhang, W.  Integrated OMICS guided engineering of biofuel butanol-tolerance in photosynthetic Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2013, 6(1):106. (IF=6.444, 一区)

(55) 巫琴,陈磊,王江新,张卫文。应用合成生物学策略优化光合蓝细菌底盘。生物工程学报 2013,29(8):1086-1099

(56) Qiao, J., Huang, S., Te, R., Wang, J., Chen, L., Zhang, W. Integrated proteomic and transcriptomic analysis reveals novel genes and regulatory mechanisms involved in salt stress responses in Synechocystis sp. PCC 6803. Applied Microbiology and Biotechnology 2013, 97(18):8253-8264. (IF=3.376, 二区)

(57) Huang, S., Chen, L., Te, R., Qiao, J., Wang, J., Zhang, W. Complementary iTRAQ proteomics and RNA-seq transcriptomics reveal multiple levels of regulation in response to nitrogen starvation in Synechocystis sp. PCC 6803. Molecular Biosystems 2013, 9(10):2565-2574. (IF=2.829, 三区)

(58) Wang, J., Chen, L., Huang, S., Liu, J., Ren, X., Tian, X., Qiao, J., Zhang, W. RNA-seq based identification and mutant validation of gene targets related to ethanol resistance in cyanobacterial Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2012, 5(1):89. (IF=6.444, 一区)

(59) Wang, J., Wu, G., Chen, L., Zhang, W. Cross-species transcriptional network analysis reveals conservation and variation in response to metal stress in cyanobacteria. BMC Genomics 2013, 14:112. (IF=3.867, 二区)

(60) Liu, J., Chen, L., Wang, J., Qiao, J., Zhang, W. Proteomic analysis reveals resistance mechanism against biofuel hexane in Synechocystis sp. PCC 6803. Biotechnology for Biofuels 2012, 5(1):68. (IF=6.444, 一区)

(61) Tian, X., Chen, L., Wang, J., Qiao, J., Zhang, W. Quantitative proteomics reveals dynamic responses of Synechocystis sp. PCC 6803 to next-generation biofuel butanol. Journal of Proteomics 2013, 78:326-345. (IF=3.867, 二区)

(62) Qiao, J., Wang, J., Chen, L., Tian, X., Huang, S., Ren, X., Zhang, W. Quantitative iTRAQ LC-MS/MS Proteomics Reveals Metabolic Responses to Biofuel Ethanol in Cyanobacterial Synechocystis sp. PCC 6803. Journal of Proteome Research 2012, 11(11):5286-5300. (IF=4.173, 二区)

(63) Qiao, J., Chen, L., Li, Y., Wang, J., Zhang, W., Chen, S. Whole-Genome Sequence of Nocardiopsis alba Strain ATCC BAA-2165, Associated with Honeybees. Journal of Bacteriology 2012, 194(22):6358-6359. (IF=3.198, 三区)

(64) Qiao, J., Shao, M., Chen, L., Wang, J., Wu, G., Tian, X., Liu, J., Huang, S., Zhang, W. Systematic characterization of hypothetical proteins in Synechocystis sp. PCC 6803 reveals proteins functionally relevant to stress responses. Gene 2013, 512(1):6-15. (IF=2.319, 四区)

(65) Chen, L., Ge, X., Wang, X., Patel, J.R., Xu, P. SpxA1 involved in hydrogen peroxide production, stress tolerance and endocarditis virulence in Streptococcus sanguinis. PLoS ONE 2012, 7(6): e40034. (IF=3.057, 三区)

(66) Lei, A., Chen, H., Shen, G., Hu, Z., Chen, L., Wang, J. Expression of fatty acid synthesis genes and fatty acid accumulation in haematococcus pluvialis under different stressors. Biotechnology for Biofuels 2012, 5(1):18. (IF=6.444, 一区)

(67) Xu, P., Ge, X., Chen, L., Wang, X., Dou, Y., Xu, J.Z., Patel, J.R., Stone, V., Trinh, M., Evans, K., Kitten, T., Bonchev, D., Buck, G.A. Genome-wide essential gene identification in Streptococcus sanguinis. Scientific Reports 2011, 1:125. (IF=5.228, 二区)

(68) Chen, L., Ge, X., Dou, Y., Wang, X., Patel, J.R., Xu, P. Identification of hydrogen peroxide production related genes in Streptococcus sanguinis and their functional relationship with pyruvate oxidase. Microbiology 2011, 157:13-20. (IF=2.268, 三区)

(69) Chen, L., Chen, J., Jiang, Y., Zhang, W., Jiang, W., Lu, Y. Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis. FEMS Microbiology Letters 2009, 298(2):199-207. (IF=1.858, 四区)

(70) Wang, W., Shu, D., Chen, L., Jiang, W., Lu, Y. Cross-talk between an orphan response regulator and a noncognate histidine kinase in Streptomyces coelicolor. FEMS Microbiology Letters 2009, 294(2):150-156. (IF=1.858, 四区)

(71) Shu, D., Chen, L., Wang, W., Yu, Z., Ren, C., Zhang, W., Yang, S., Lu, Y., Jiang, W. afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolismg and morphological development in Streptomyces coelicolor. Applied Microbiology and Biotechnology 2009, 81(6):1149-1160. (IF=3.376, 二区)

(72) Chen, L., Lu, Y., Chen, J., Zhang, W., Shu, D., Qin, Z., Yang, S., Jiang, W. Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. Applied Microbiology and Biotechnology 2008, 80(2):277-286. (IF=3.376, 二区)

(73) Lu, Y., Wang, W., Shu, D., Zhang, W., Chen, L., Qin, Z., Yang, S., Jiang, W. Characterization of a novel two-component regulatory system involved in the regulation of both actinorhodin and a type I polyketide in Streptomyces coelicolor. Applied Microbiology and Biotechnology 2007, 77(3):625-635. (IF=3.376, 二区)

(74) Chen, L., Yu, H., Lu, Y., Jiang, W. Cloning and preliminary characterization of lh3 gene encoding a putative acetyltransferase from a rifamycin SV-producing strain Amycolatopsis mediterranei. Biotechnology Letters 2005, 27(15):1129-1134. (IF=1.639, 三区)