SCHOOL OF CHEMICAL ENGINEERING
师资队伍
Teachers查询:
教授
卢文玉
现任职称/职务:教授/博导通讯地址:天津大学北洋园校区54-226
电子邮箱:wenyulu@tju.edu.cn
办公电话:13803004025
论著专利:
2007年留校工作以来发表文章70余篇,其中以第一或通讯作者发表SCI文章50余篇。
部分文章列表:
2019
1. Zhao Fanglong, Bai Peng, Nan Weihua, Li Dashuai, Zhang Chuanbo, Lu Chunzhe, Qi Haishan, Lu Wenyu*. A modular engineering strategy for high-level production of protopanaxadiol from ethanol by Saccharomyces cerevisiae [J]. AIChE Journal, 2019, 65(3): 866-874.
2. Sun Jie, Zhang Chuanbo, Nan Weihua, Li Dashuai, Ke Di, Lu Wenyu*. Glycerol improves heterologous biosynthesis of betulinic acid in engineered Yarrowia lipolytica[J]. Chemical Engineering Science, 2019, 196: 82-90.
3. Liu S, Diao N, Wang Z, et al. Modular engineering of the flavin pathway in Escherichia coli for improved flavin mononucleotide and flavin adenine dinucleotide production[J]. Journal of agricultural and food chemistry, 2019. 67(23): 6532-6540.
4. Zhao Fanglong, Zhang Chuanbo, Nan Weihua, Lu Wenyu*. An integrated bioprocess for fermentative production of protopanaxadiol by recycling ethanol waste during down-stream extraction process[J]. Journal of Cleaner Production, 2019, 234: 1-8.
5. Liu Jingjing, Zhang Chuanbo, Lu Wenyu*. Biosynthesis of long-chain ω-hydroxy fatty acids by engineered Saccharomyces cerevisiae[J]. Journal of agricultural and food chemistry, 2019, 67(16): 4545-4552
6. Zhang Chuanbo, Ju Haiyan, Lu Chun-Zhe, Zhao Fanglong, Liu Jingjing, Guo Xiaoyan, Wu Yufen, Zhao Guang-Rong, Lu Wenyu*. High-titer production of 13-R manoyl oxide in metabolically engineered Saccharomyces cerevisiae [J]. Microbial cell factories, 2019, 18(1): 73-81
7. Jia Dan, Xu Shuo, Sun Jie, Zhang Chuanbo, Li Dashuai, Lu Wenyu*. Yarrowia lipolytica construction for heterologous synthesis of α-santalene and fermentation optimization[J]. Applied Microbiology and Biotechnology, 2019, 103(8): 3511-3520.
8. Li Dashuai, Wu Yufen, Zhang Chuanbo, Sun Jie, Zhou Zhijiang, Lu Wenyu*. Production of triterpene ginsenoside compound K in the nonconventional yeast Yarrowia lipolytica [J]. Journal of Agricultural and Food Chemistry, 2019, 67(9): 2581–2588.
9. Wu Yufen, Xu Shuo, Gao Xiao, Li Man, Li Dashuai, Lu Wenyu*. Enhanced protopanaxadiol production from xylose by engineered Yarrowia lipolytica [J]. Microbial Cell Factories, 2019, 18(1): 83-94.
10. Guo Xiaoyan, Liu Jingjing, Zhang Chuanbo, Zhao Fanglong, Lu Wenyu*. Stepwise increase in the production of 13R-manoyl oxide through metabolic engineering of Saccharomyces cerevisiae [J]. Biochemical Engineering Journal, 2019, 144: 73-80.
11. Lu Wenyu, Zhu Baozhong, Jia Xiaoqiang*; Development and Optimization of Oil Spill Dispersant for High Viscosity Oil Spill; Transactions of Tianjin University; 52(1); 2019; 26-32.
12. Tan Jinxiu, Yang Xiaona, Lu Wenyu*. Research of 1, 3-dihydroxyacetone production by overexpressing glycerol transporter and glycerol dehydrogenase[J]. Transactions of Tianjin University, 2019, 1-10.
2018
13. Zhang Chuanbo, Liu Jingjing, Zhao Fanglong, Lu Chunzhe, Zhao Guang-Rong Lu Wenyu*. Production of sesquiterpenoid zerumbone from metabolic engineered Saccharomyces cerevisiae[J]. Metabolic Engineering, 2018, 49: 28-35.
14. Lu Chun-Zhe, Zhang Chuanbo, Zhao Fanglong, Li Dashuai, Lu Wenyu*. Biosynthesis of ursolic acid and oleanolic acid in Saccharomyces cerevisiae [J]. AIChE Journal, 2018, 64(11): 3794-3802.
15. Gao Xiao, Caiyin Qinggele, Zhao Fanglong, Yufen Wu, Lu Wenyu*. Engineering Saccharomyces cerevisiae for enhanced production of protopanaxadiol with cofermentation of glucose and xylose[J]. Journal of Agricultural and Food Chemistry, 2018. 66(45): 12009–12016.
16. Liu Ting, Zhang Chuanbo, Lu Wenyu*. Heterologous production of levopimaric acid in Saccharomyces cerevisiae [J]. Microbial cell factories, 2018, 17 (1): 114-123.
17. Guo Xiaoyan, Sun Jie, Li Dashuai, Lu Wenyu*. Heterologous biosynthesis of (+)-nootkatone in unconventional yeast Yarrowia lipolytica[J]. Biochemical Engineering Journal, 2018, 137: 125-131.
18. Zhang Yaguang, Jia Dan, Sun Wanqi, Yang Xue, Zhang Chuanbo, Zhao Fanglong, Lu Wenyu*. Semicontinuous sophorolipid fermentation using a novel bioreactor with dual ventilation pipes and dual sieve‐plates coupled with a novel separation system[J]. Microbial biotechnology, 2018, 11(3): 455-464.
19. Ke Di, Caiyin Qinggele, Zhao Fanglong, Liu Ting, Lu Wenyu*. Heterologous biosynthesis of triterpenoid ambrein in engineered Escherichia coli[J]. Biotechnology letters, 2018, 40(2): 399-404.
20. Zhang Chuanbo, Ke Di, Duan Yuejiao, Lu Wenyu*. The combinatorial biosynthesis of “unnatural” products with polyketides[J]. Transactions of Tianjin University, 2018, 24(6): 501-512.
21. Liu Zhen, Wang Yiting, Jia Xiaoqiang, Lu Wenyu*. Isolation of secondary metabolites with antimicrobial activities from Bacillus amyloliquefaciens LWYZ003[J]. Transactions of Tianjin University, 2018, 25 (1): 1-7.
2017
22. Zhao Fanglong, Du Yanhui, Bai Peng, Liu Jingjing, Lu Wenyu*, Yuan Yingjin. Enhancing Saccharomyces cerevisiae reactive oxygen species and ethanol stress tolerance for high-level production of protopanoxadiol[J]. Bioresource technology, 2017, 227: 308-316.
23. Lu Chunzhe, Yin Jin, Zhang Chuanbo, Lu Wenyu*. Fed-Batch Fermentation for Spinosad Production in an Improved Reactor[J]. Transactions of Tianjin University, 2017, 23(6): 530-537.
24. Ting Liu,Xiangmei Zhang,Fanglong Zhao, Lu Wenyu*.Molecular simulation and catalytic active sites identification of dammarenediol-Ⅱ synthase[J].Journal of Beijing Institute of Technology, 2017, 26(04):563-570.
25. Lu Chunzhe, Yin Jin, Zhao Fanglong, Li Feng Lu Wenyu*. Metabolomics analysis of the effect of dissolved oxygen on spinosad production by Saccharopolyspora spinosa[J]. Antonie van Leeuwenhoek, 2017, 110 (5): 677-685.
2016
26. Zhao Fanglong, Bai Peng, Liu Ting, Li Dashuai, Zhang xiangmei, Lu Wenyu*, Yuan Yingjin.. Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae[J]. Biotechnology and bioengineering, 2016, 113(8): 1787-1795.
27. Li Dashuai, Zhang Qiang, Zhou Zhijiang, Zhao Fanglong Lu Wenyu*. Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli[J]. Biotechnology letters, 2016, 38(4): 603-609.
2015
28. Lin Fujian, Guo Xiaoyan, Lu Wenyu*. Efficient biotransformation of ginsenoside Rb1 to Rd by isolated Aspergillus versicolor, excreting β-glucosidase in the spore production phase of solid culture[J]. Antonie van Leeuwenhoek, 2015, 108(5): 1117-1127.
29. Zhang Chuanbo, Xue Chaoyou, Shen Yueqi, Lu Wenyu*. Selection of reference genes in Saccharopolyspora spinosa for real-time PCR[J]. Transactions of Tianjin University, 2015, 21(5): 461-467.
30. Zhao Fanglong, Zhang Chuanbo, Yin Jin, Shen Yueqi Lu Wenyu*. Coupling of spinosad fermentation and separation process via two-step macroporous resin adsorption method[J]. Applied biochemistry and biotechnology, 2015, 176(8): 2144-2156.
31. Hu Cheng, Lu Wenyu*. Insight into yeast: a study model of lipid metabolism and terpenoid biosynthesis[J]. Biotechnology and applied biochemistry, 2015, 62(3): 323-328.
2014
32. Wu Xinsen, Wang Xiaoyang, Lu Wenyu*. Genome-scale reconstruction of a metabolic network for Gluconobacter oxydans 621H[J]. Biosystems, 2014, 117: 10-14.
33. Wang Xiaoyang, Zhang Chuanbo, Wang Meiling, Lu Wenyu*. Genome-scale metabolic network reconstruction of Saccharopolyspora spinosa for Spinosad Production improvement[J]. Microbial cell factories, 2014, 13(1): 41-47.
34. Zhang Xiangmei, Xue Chaoyou, Zhao Fanglong, Li Dashuai, Yin Jing, Zhang Chuanbo, Caiyin Qinggele, Lu Wenyu*. Suitable extracellular oxidoreduction potential inhibit rex regulation and effect central carbon and energy metabolism in Saccharopolyspora spinosa[J]. Microbial cell factories, 2014, 13(1): 98-108.
2013
35. Xue Chaoyou, Duan Yuejiao, Zhao Fanglong, Lu Wenyu*. Stepwise increase of spinosad production in Saccharopolyspora spinosa by metabolic engineering[J]. Biochemical engineering journal, 2013, 72: 90-95.
36. Zhao Fanglong, Xue Chaoyou, Wang Meiling, Wang Xiaoyang Lu Wenyu*. A comparative metabolomics analysis of Saccharopolyspora spinosa WT, WH124, and LU104 revealed metabolic mechanisms correlated with increases in spinosad yield[J]. Bioscience, biotechnology, and biochemistry, 2013, 77(8): 1661-1668.
37. Xue Chaoyou, Zhang Xiangmei, Yu Zhirui, Zhao Fanglong, Wang Meiling, Lu Wenyu*. Up-regulated spinosad pathway coupling with the increased concentration of acetyl-CoA and malonyl-CoA contributed to the increase of spinosad in the presence of exogenous fatty acid[J]. Biochemical engineering journal, 2013, 81: 47-53.
2012
38. Zhu Lingqing, Yang Xue, Xue Chaoyou, Chen Yu, Qu Liang Lu Wenyu*. Enhanced rhamnolipids production by Pseudomonas aeruginosa based on a pH stage-controlled fed-batch fermentation process[J]. Bioresource technology, 2012, 117: 208-213.
39. Yang Xue, Zhu Lingqing, Xue Chaoyou, Chen Yu, Qu Liang Lu Wenyu*. Recovery of purified lactonic sophorolipids by spontaneous crystallization during the fermentation of sugarcane molasses with Candida albicans O-13-1[J]. Enzyme and microbial technology, 2012, 51(6): 348-353.
40. Wu Xinen, Xia Zhendong, Yang Xue, Xue Chaoyou Lu Wenyu*. Molecular simulation of pyrroloquinoline quinine-dependent glycerol dehydrogenase in Gluconobacter oxydans[J]. Molecular Simulation, 2012, 38(12): 1010-1014.
Before 2011
41. Lu Wenyu,Fan Jinghua,Wen Jianping,Xia Zhendong,Caiyin Qinggele,Kinetic Analysis and Modeling of Daptomycin Batch Fermentation by Streptomyces roseosporus,Applied Biochemistry and Biotechnology,2011,163(4):453-462.
42. Lu Wenyu,Wen Jianping,Jia Xiaoqiang,Sun Bing,Chen Yu,Liu Minhui. Effect of He-Ne laser irradiation on hydrogen production by Enterobacter aerogenes,International Journal of Hydrogen Energy,2008,33(1):34-42.
43. Lu Wenyu,Wen Jianping,Chen Yu,Sun Bing,Jia Xiaoqiang,Liu Minghui,Caiyin Qinggele,Synergistic effect of Candida maltosa HY-35 and Enterobacter aerogenes W-23 on hydrogen production,International Journal of Hydrogen Energy,2007,32(8):1059-1066.
授权专利:
1. 卢文玉,尹静,张传波,生物反应器,专利号:ZL201420684713.X
2. 卢文玉,王晓阳,张传波,刺糖多孢菌基因组尺度代谢网络模型及构建方法及应用,专利号:ZL201310756418.0
3. 卢文玉,王美玲,赵方龙,一种多杀菌素的发酵方法,专利号:ZL201310756416.1
4. 卢文玉,薛朝友,张香梅,能提高多杀菌素产量的基因工程菌及构建方法及应用,专利号:ZL201310756049.5
5. 卢文玉,赵方龙. 能提高达玛烯二醇转化效率的融合蛋白质及构建方法及应用, 专利号:ZL201410734624.6
6. 卢文玉,赵方龙.能提高达玛烯二醇转化效率的融合蛋白质及构建方法,专利号:ZL201410736994.3
7. 卢文玉,赵方龙.一种能提高达玛烯二醇转化效率的融合蛋白质及构建方法及应用, 专利号:ZL201410735927.X
8. 卢文玉,李大帅,张强,赵方龙.合成达玛烯二醇的大肠杆菌基因工程菌株及构建方法,专利号:ZL201510672700.X
9. 卢文玉,张亚光,杨雪. 一种槐糖脂发酵生物分离系统及方法,中国发明专利,专利号:ZL201610343815.9
10. 卢文玉,林福建,郭校燕,一种转化人参皂苷Rb1生产Rd的曲霉及应用,专利号:ZL201510543267x
编著教材:
参编《微生物工程技术原理》