SCHOOL OF CHEMICAL ENGINEERING

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教授

张 麟

现任职称/职务:教授
通讯地址:天津大学化工学院生物化工系
电子邮箱:linzhang@tju.edu.cn
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论著专利:

相关结果已发表SCI论文30余篇(第一或通讯作者),获授权中国和美国发明专利多项(第一发明人)。


论文:

[1] Chen Xie, Lin Zhang*, Design and characterization of antithrombotic ClEKnsTy-Au nanoparticles as diagnostic and therapeutic reagents, Physical Chemistry Chemical Physics, 2023, 25, 20422–20429.
[2] Ran Chen, Si Zheng, Lin Zhang*, Development of antithrombotic peptides based on the molecular interactions between von Willebrand factor and GPIbα, Physical Chemistry Chemical Physics, 2022, 24, 22670–22678. (SCI, 4X5VO)
[3] Si Zheng#, Tanyi Hao#, Lin Zhang*, Development of the antithrombotic peptide LEKNSTY targeting the collagen surface: I. Design and validation, Langmuir, 2022, 38(23):7107–7113, DOI: 10.1021/acs.langmuir.2c00586. (SCI, 2E0KL)
[4] Si Zheng#, Zhao Ye#, Yufan Ji, Nanxing Li, Lin Zhang*, Development of antithrombotic peptide LEKNSTY targeting collagen surface: II. Improvement of plasma stability, Langmuir, 2022, 38(23):7114-7120. DOI: 10.1021/acs.langmuir.2c00587. (SCI, 2D9UD)
[5] Xiaoyang Li#, Yufei Cao#, Kai Luo, Lin Zhang*, Yunxiu Bai, Jiarong Xiong, Richard N. Zare*, Jun Ge*, Cooperative catalysis by a single-atom enzyme-metal complex, Nature Communications, 2022, 13: 2189. (SCI, 0Q6CJ)
[6] Yi Feng#, Xun Cao#, Lin Zhang*, Jingyi Li, Shitong Cui, Yunxiu Bai, Kequan Chen, Jun Ge*, Defect engineering of enzyme-embedded metal–organic frameworks for smart cargo release, Chemical Engineering Journal, 2022, 439: 135736. (SCI, 2P9XU)
[7] Yuanyuan Chao, Lin Zhang*, Biomimetic Design of Inhibitors of Immune Checkpoint LILRB4, Biophysical Chemistry, 2022, 282: 106746. (SCI, 0X3SL) (Q3)
[8] Na Sun#, Zhao Ye#, Tanyi Hao, Si Zheng, Yan Sun, Youcai Zhang*, Lin Zhang*, Inhibition of arterial thrombus formation by blocking exposed collagen surface using LWWNSYY-poly (L-glutamic acid) nanoconjugate, Langmuir, 2021, 37(22):6792-6799. (SCI, SS1AX)
[9] 李南星,张麟*,靶向于Galectin-10蛋白的哮喘抑制剂设计,化工学报,2021, 72(9): 4847-4853. (EI)
[10] Qianqian Hou, Lin Zhang*, Biomimetic Design of Peptide Neutralizer of Ebola Virus with Molecular Simulation, Langmuir, 2020, 36(7): 1813−1821, DOI: 10.1021/acs.langmuir.9b03832. (SCI, KR1AE)
[11] Shihao Li, Lin Zhang*, Erythrocyte membrane nano-capsules: biomimetic delivery and controlled release of photothermal-photochemical coupling agents for cancer cell therapy, Dalton Transactions, 2020, 49(8): 2645–2651, DOI: 10.1039/c9dt04335g. (SCI, KS0GM) (230424查询为Q1)
[12] Qianqian Hou, Nanxing Li, Yuanyuan Chao, Shihao Li, Lin Zhang*, Design and Regulation of the Surface and Interfacial Behavior of Protein Molecules, Chinese Journal of Chemical Engineering, 2020, 28(11): 2837–2847. DOI: 10.1016/j.cjche.2020.05.035.
[13] 李诗浩,张麟*,红细胞膜封装负载姜黄素的金纳米粒子,精细化工,2020, 37(9): 1819-1824. (EI)
[14] Xiaoling Wu, Hua Yue, Yuanyu Zhang, Xiaoyong Gao, Xiaoyang Li, Licheng Wang, Yufei Cao, Miao Hou, Haixia An, Lin Zhang*, Sai Li*, Jingyuan Ma, Wei Wei*, Jun Ge*, Richard N. Zare, Wenyong Lou, He Lin, Hongkai Gu, Packaging and delivering enzymes by amorphous metal-organic frameworks, Nature Communications, 2019, 10: 5165, DOI: 10.1038/s41467-019-13153-x (SCI, JM7SP)
[15] 李郭安, 张麟*, 鼠多瘤病毒样颗粒及其在疫苗开发等方面的研究进展, 生物化学与生物物理进展, 2019, 46(8): 760–771, DOI: 10.16476/j.pibb.2019.0099. (SCI, IT0OQ)
Guoan Li, Lin Zhang*, Research Progress of Murine Polyomavirus Virus-like Particle and Its Application in Vaccine Development, Progress in Biochemistry and Biophysics, 2019, 46(8): 760-771.
[16] 张麟*, 陈衡, 正负电荷改性乙肝病毒样颗粒的构建及性能评价, 天津大学学报(自然科学与工程技术版), 2019, DOI:10.11784/tdxbz201904068. (EI)
[17] Lin Zhang, Yan Sun*, Charged Surface Regulates the Molecular Interactions of Electrostatically Repulsive Peptides by Inducing Oriented Alignment. Langmuir, 2018, 34(14): 4390–4397. (SCI, GC8DI, 2018.4.10, IF 4.384)
[18] Fenfen You, Yan Sun, Lin Zhang*, Design of biomimetic surface for fabrication of monodispersed silver nanoparticles with high catalytic activity, Materials Letters, 2018, 229: 316–319. (SCI, GQ1NW, IF3.019, 2018.10.15)
[19] 张麟, 孙彦*, 蛋白质色谱界面行为的分子模拟, 化工学报, 2018, 69(01): 156-165. (EI)
Lin Zhang, Yan Sun*, Molecular simulation on interfacial behaviors of protein at chromatographic surface, Journal of Chemical Industry and Engineering(China), 2018, 69(01): 156-165.
[20] 张麟*, 郝坛义, 靶向于胶原蛋白的血栓抑制剂LERNSTY开发, 天津大学学报(自然科学与工程技术版), 2018, 51(04): 401-405. (EI, 20183405731314) 2018.4.15, DOI: 10.11784/tdxbz201704012
Lin Zhang*, Tanyi Hao, Development of Thrombus Inhibitor LERNSTY Targeted at Collagen, Journal of Tianjin University (Science and Technology), 2018, 51(04): 401-405.
[21] 张麟*, 孙娜, 血栓纳米抑制剂m5k-BAD-L的构建及其性能研究, 天津大学学报(自然科学与工程技术版), 2017, 50(5): 477–482. (EI, 20173604116239) 2017.5.17, DOI:10.11784/tdxbz201603079
Lin Zhang*, Na Sun, Design and Characterization of Antithrombotic Nanoconjugate―m5k-BAD-L, Journal of Tianjin University (Science and Technology), 2017, 50(5): 477–482. 
[22] Wenchao Zhang, Yan Sun, Lin Zhang*, Fabrication of High Efficient Silver Nanoparticle Catalyst Supported on Poly(glycidyl methacrylate)-polyacrylamide. Industrial & Engineering Chemistry Research, 2016, 55(48): 12398–12406. (SCI, EE5CY)
[23] Chao Zhang, Lin Zhang*, Youcai Zhang, Na Sun, Shaoyi Jiang, Timothy J. Fujihara, Yan Sun*, Development of antithrombotic nanoconjugate blocking integrin α2β1-collagen interactions. Scientific Reports, 2016, 6, 26292. (SCI, DM5EX)
[24] Lin Zhang, Linda HL Lua, Anton PJ Middelberg, Yan Sun, Natalie K. Connors*, Biomolecular Engineering of Virus-Like Particles Aided by Computational Chemistry Methods. Chemical Society Reviews, 2015, 44(23): 8608–8618. (SCI, CW2WI, IF 30.425)
[25] Wenchao Zhang, Yan Sun, Lin Zhang*, In Situ Synthesis of Monodisperse Silver Nanoparticles on Sulfhydryl-Functionalized Poly(glycidyl methacrylate) Microspheres for Catalytic Reduction of 4-Nitrophenol. Industrial & Engineering Chemistry Research, 2015, 54(25): 6480–6488. (SCI, CM1JG, IF 2.235)
[26] Wenchao Zhang, Lin Zhang*, Yan Sun, Size-Controlled Green Synthesis of Silver Nanoparticles Assisted by L-Cysteine. Frontiers of Chemical Science and Engineering, 2015, 9(4): 494–500. (SCI, CX5RF)
[27] Linling Yu#, Lin Zhang#, Yan Sun*, Protein behavior at surfaces: Orientation, conformational transitions and transport. Journal of Chromatography A, 2015, 1382C: 118–134. (SCI, CB6IB, IF 4.258)
[28] Lin Zhang, Ronghong Tang, Shu Bai, Natalie K. Connors, Linda HL Lua, Yap P. Chuan, Anton PJ Middelberg, Yan Sun*, Energetic changes caused by antigenic module insertion in a virus-like particle revealed by experiment and molecular dynamics simulations. PLoS ONE, 2014, 9(9): e107313–12. (SCI, AP0SM, IF 3.534)
[29] Yanying Li, Xiaodan Liu, Xiaoyan Dong, Lin Zhang*, Yan Sun*, Biomimetic Design of Affinity Peptide Ligand for Capsomere of Virus-Like Particle. Langmuir, 2014, 30(28): 8500–8508. (SCI, AL9LQ, IF 4.384)
[30] Lin Zhang, Yan Sun*, Biomimetic design of platelet adhesion inhibitors to block integrin α2β1-collagen interactions: I. Construction of affinity binding model. Langmuir, 2014, 30(16): 4725–4733. (SCI, AG3DZ, IF 4.384)
[31] Lin Zhang, Chao Zhang, Yan Sun*, Biomimetic design of platelet adhesion inhibitors to block integrin α2β1-collagen interactions: II. Inhibitor library, screening and experimental validation. Langmuir, 2014, 30(16): 4734–4742. (SCI, AG3DZ, IF 4.384)
[32] 董晓燕,刘晓丹,张麟*, 内含肽介导的鼠多瘤病毒样颗粒生产表达和纯化, 天津大学学报(自然科学与工程技术版), 2014, 47(04): 315–320. (EI, 20142117742905)
Xiaoyan Dong, Xiaodan Liu, Lin Zhang*, Intein-Mediated Expression and Purification of Murine Polyomavirus Virus-Like Particles, Journal of Tianjin University (Science and Technology), 2014, 47(04): 315–320. (EI, 20142117742905)
[33] Lin Zhang, Ronghong Tang, Shu Bai, Natalie K. Connors, Linda HL Lua, Yap P. Chuan, Anton PJ Middelberg, Yan Sun*, Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations. Journal of Physical Chemistry B, 2013, 117(18): 5411–5421. (SCI, 143TS, IF 3.607)
[34] 白姝, 李浩, 张麟*, 静电排斥表面诱导溶菌酶分子站立, 物理化学学报, 2013, 29 (4), 849–857. (SCI, 116EB, IF 0.869)
Shu Bai, Hao Li, Lin Zhang*, Standing orientation of lysozymes induced by electrostatically repulsive surface, Acta Physico-Chimica Sinica, 2013, 29(4): 849–857. (SCI, 116EB, IF 0.869)
[35] 白姝, 唐荣宏, 张麟*, 衣壳粒蛋白稳定性的分子动力学模拟, 化学工业与工程, 2013, 30(6): 62–66. (核心)
Shu Bai, Ronghong Tang, Lin Zhang*, Molecular Dynamics Simulation of the Stability of Capsomere, Chemical Industry and Engineering, 2013, 30(6): 62–66.
[36] Lin Zhang, Yan Sun*, Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics simulations, Frontiers of Chemical Science and Engineering, 2013, 7(4): 456–463. (SCI, V39BH)
[37] Guangjie Han, Xiaoyan Dong, Lin Zhang*, Litang Fu, Guozhen Wang, Yan Sun*, Facilitated oxidative refolding of ribonuclease A from inclusion bodies with a new redox system, Biochemical Engineering Journal, 2012, 69 (15): 106–112. (SCI, 052DS, IF 2.645)
[38] Jian Li, Lin Zhang, Yan Sun*, Molecular basis of the initial platelet adhesion in arterial thrombosis: molecular dynamics simulations, Journal of Molecular Graphics and Modelling, 2012, 37: 49–58. (SCI, 969AD, IF 2.184)
[39] Guofeng Zhao, Lin Zhang*, Shu Bai, Yan Sun*, Analysis of hydrophobic charge induction displacement chromatography by visualization with confocal laser scanning microscopy, Separation and Purification Technology, 2011, 82: 138–147. (SCI, 845OD, IF 2.775) 
[40] Lin Zhang, Shu Bai, Yan Sun*, Modification of Martini force field for molecular dynamics simulation of hydrophobic charge induction chromatography of lysozyme, Journal of Molecular Graphics and Modelling, 2011, 29(7): 906–914. (SCI, 774VL, IF 2.038)
[41] Lin Zhang, Guofeng Zhao, Yan Sun*, Effects of ligand density on hydrophobic charge induction chromatography: a molecular dynamics simulation. Journal of Physical Chemistry B, 2010, 114 (6): 2203–2211. (SCI, 553GV, IF 3.603)
[42] Lin Zhang, Shu Bai, Yan Sun*, Molecular dynamics simulation of the effect of ligand homogeneity on protein behavior in hydrophobic charge induction chromatography, Journal of Molecular Graphics and Modelling, 2010, 28(8): 863–869. (SCI, 606HY, IF 2.038)
[43] Lin Zhang, Yan Sun*, Molecular simulation of adsorption and its implications to protein chromatography: a review. Biochemical Engineering Journal, 2010, 48 (3): 408–415. (SCI, 576CO, IF 2.692)
[44] Lin Zhang, Guofeng Zhao, Yan Sun*, Molecular dynamics simulation and experimental validation for the effect of pH on protein desorption in hydrophobic charge induction chromatography, Molecular Simulation, 2010, 36(13): 1096–1103. (SCI, 685KP, IF 1.215)
[45] Lin Zhang, Guofeng Zhao, Yan Sun*, Molecular insight into protein conformational transition in hydrophobic charge induction chromatography: a molecular dynamics simulation, Journal of Physical Chemistry B, 2009, 113(19): 6873–6880. (SCI, 443CP, IF 3.603)
[46] Lin Zhang, Diannan Lu, Zheng Liu*, Dynamic control of protein conformation transition in chromatographic separation based on hydrophobic interactions: Molecular dynamics simulation, Journal of Chromatography A, 2009, 1216(12): 2483-2490. (SCI, 419KH, IF 4.194)
[47] Lin Zhang, Diannan Lu, Zheng Liu*, How native proteins aggregate in solution: a dynamic Monte Carlo simulation, Biophysical Chemistry. 2008, 133(1-3): 71-80. (SCI, 268ZQ, IF 2.108)
[48] 张麟,卢滇楠,刘铮*, 高分子抑制蛋白质聚集的动态Monte Carlo模拟, 化工学报, 2008, 59(01), 153-159. (EI, 080811110678)
Lin Zhang, Diannan Lu, Zheng Liu*, Dynamic Monte Carlo simulation on protein aggregation and its inhibition by polymer, Journal of Chemical Industry and Engineering(China), 2008, 59(01), 153-159. (EI, 080811110678)
[49] 张麟,卢滇楠,刘铮*,分子动力学模拟尿素对水溶液中蛋白质构象转变的影响, 生物加工过程, 2006, 4(03), 38-43. (核心)
Lin Zhang, Diannan Lu, Zheng Liu*, The effect of urea on the conformational transition of protein in aqueous by molecular dynamics simulations, Chinese Journal of Bioprocess Engineering, 2006, 4(03), 38-43.

专利:

[1] Lin Zhang, Xiaoyan Dong, Yanying Li, Xiaodan Liu, Yan Sun, Affinity peptide ligand of mouse polyomavirus capsomer and designed screening method thereof, US9920094B2, Data of Patent: Mar. 20, 2018, United States Patent and Trademark Office.
[2] 张麟,董晓燕,李艳英,刘晓丹,孙彦,鼠多瘤病毒衣壳粒的新型亲和肽配基及其设计筛选方法,授权公告日2016.4.13,专利号ZL201410276200.X
[3] 张麟,孙彦,张超,针对血栓形成过程中胶原蛋白-整联蛋白α2β1相互作用的纳米抑制剂及制备方法和应用,授权公告日2018.4.10,专利号ZL201510176072.6
[4] 张麟,孙彦,郭小翠,一种通过正负电荷引入辅助病毒样颗粒自组装的方法和应用,专利号ZL201710104570.9,授权日2020.3.17
[5] 张麟,孙彦,游粉粉,一种单分散高催化性能溶液态银纳米颗粒的合成方法和应用,专利号ZL201710156412.8,授权日2020.3.27
[6] 张麟,孙彦,陈衡,一种重组病毒衣壳结构蛋白及其制备方法和应用,专利号ZL201811602294.X,授权日2021.4.23
[7] 张麟,李南星,一种靶向于Galectin-10蛋白的抑制剂仿生设计筛选方法以及哮喘抑制剂,专利号ZL202110290228.9,授权日2022.7.19