SCHOOL OF CHEMICAL ENGINEERING

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教授

董 敏

现任职称/职务:教授/博导 制药工程系
通讯地址:天津大学北洋园校区化工学院
电子邮箱:mindong@tju.edu.cn
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论著专利:

14.   Dong, M.; Kathiresan, V.; Fenwick, M. K.; Torelli, A. T.; Zhang, Y.; Caranto, J. D; Dzikovski, B.; Sharma, A.; Lancaster, K. M.; Freed, J. H.; Ealick, S. E.; Hoffman, B. M.; Lin, H. Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science  2018. 359, 1247-1250.

13.   Dong, M.; Zhang, Y.G.; Lin, H. Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis. Methods Enzymol. 2018, 606, 421-438.

12.  Dong, M.; Zhang, Y.G.; Lin, H. Noncanonical Radical SAM Enzyme Chemistry Learned from Diphthamide Biosynthesis. Biochemistry  2018. 57, 3454–3459. (Invited Perspective).

11.    Dong, M.; Horitani, M.; Dzikovski, B.; Freed, J. H.; Ealick, S. E.; Hoffman, B. M.; Lin, H. Substrate-Dependent Cleavage Site Selection by Unconventional Radical S‑Adenosylmethionine  Enzymes in Diphthamide Biosynthesis. J. Am. Chem. Soc. 2017. 139, 5680-5683

10.  Dong, M#.; Horitani, M#.; Dzikovski, B.; Pandelia, M. E.; Krebs, C.; Freed, J. H.; Hoffman, B.; Lin, H. Organometallic complex formed by an unconventional radical SAM enzyme. J. Am. Chem. Soc. 2016. 138, 9755-9758.

9.  Lin, Z.; Dong, M.; Zhang, Y.; Lee, E.; Lin, H. Cytochrome B5 reductase is a Dph3 reductase required for the tRNA wobble uridine modification. Nat. Chem. Biol. 2016. 12,995–997

8.  Dong, M.; Su, X.; Dzikovski, B. G.; Dando, E. E.; Zhu, X.; Du, J.; Freed, J. H.; Lin, H. Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. J. Am. Chem. Soc. 2014, 136, 1754−7

7.  Shrimp, J.H.; Hu, J.; Dong, M.; Wang, B.S.; MacDonald, R.J.; Jiang, H.; Hao, Q.; Yen, A.; Lin, H. Revealing CD38 cellular localization using a cell permeable, mechanism-based fluorescent small molecule probe. J. Am. Chem. Soc. 2014, 136, 5656–5663

6.  Meng, J. J.; Gao, M.; Dong, M.; Wei, Y. P.; Zhang, W. Q. Catalyzation of 1,4-additions of arylboronic acids to a,b-unsaturated substrates using nickel(I) complexes. Tetrahedron Lett. 2014, 55, 2107–2109

5.  Wu, F.F#.; Dong, M#. (Co first author); Fang,F; Sang, Y.X.; Li,Y.; Cheng, B.; Zhang, L.H.; Zhai, H.B. Direct Access to Tetrahydro[1,2]diazepinones from α,β-Epoxy-N-aziridinylimines via  Anionic Rearrangement. Org. Lett., 2013, 15 (4), 914–916

4.  Dong, M.; Si, Y. Q.; Sun, S. Y.; Pu, X. P.; Yang, Z. J.; Zhang, L. R.; Zhang, L. H.; Leung, F. P.; Lam, C. M. C.; Kwong, A. K. Y.; Yue, J. B.; Zhou, Y. Y.; Kriksunov, I. A.; Hao, Q.; Lee, H. C. Design, synthesis and biological characterization of novel inhibitors of CD38. Org. Biomol. Chem. 2011, 9, 3246−3257

3.  Dong, M#.; Kirchberger, T.#; Huang, X.C.; Yang, Z. J.; Zhang, L. R.; Guse, A. H.; Zhang, L. H. Trifluoromethylated Cyclic-ADP- Ribose Mimic: Synthesis of 8-trifluoromethyl-N1-[(5′′-O-Phosphorylethoxy)methyl]-5′-O-phosphorylinosine-5′,5′′-Cyclic pyrophosphate (8-CF3-cIDPRE) and its calcium release activity in T Cells. Org. Biomol. Chem., 2010, 8, 4705–4715.

2.  Huang, X.C.; Dong, M.; Liu.J.; Zhang, K.; Yang, Z.J.; Zhang, L.R. Zhang, L.H. Concise  syntheses of trifluoromethylated cyclic and acyclic analogues of cADPR. Molecules 2010, 15(12), 8689-8701.

1.  Yue, J.; Wei, W.; Lam, C. M. C.; Zhao, Y. J.; Dong, M.; Zhang, L. R.; Zhang, L. H.; Lee, H. C.The CD38/cADPR/Ca2+-pathway promotes cell proliferation and delays NGF-induced differentiation in PC12 cells. J. Biol. Chem. 2009, 284, 29335–29242.