陈 涛





1.Y Mao, G Li, Z Chang, R Tao, Z Cui, Z Wang*, Y Tang, T Chen*, X Zhao. Metabolic engineering of Corynebacterium glutamicum for efficient production of succinate from lignocellulosic hydrolysate. Biotechnology for biofuels 11 (1), 95.

2. D Liu, Z Mao, J Guo, L Wei, H Ma, Y Tang, T Chen, Z Wang*, X Zhao. Construction, Model-Based Analysis, and Characterization of a Promoter Library for Fine-Tuned Gene Expression in Bacillus subtilis. ACS synthetic biology 7 (7), 1785-1797.

3. Guanglu Wang, Ting Shi, Tao Chen, Xiaoyue Wang, Yongcheng Wang, Dingyu Liu, Jiaxin Guo, Jing Fu, Lili Feng, Zhiwen Wang*, Xueming Zhao. Integrated whole-genome and transcriptome sequence analysis reveals the genetic characteristics of a riboflavin-overproducing Bacillus subtilis. Metabolic Engineering. 2018, 48:138-149

4. S Zhang, D Liu, Z Mao, Y Mao, H Ma, T Chen, X Zhao, Z Wang. Model-based reconstruction of synthetic promoter library in Corynebacterium glutamicum. Biotechnology letters 40 (5), 819-827.

5. P Yan, Y Wu, L Yang, Z Wang, T Chen*.Engineering genome-reduced Bacillus subtilis for acetoin production from xylose. Biotechnology letters 40 (2), 393-398.

6. X Li, C Huang, X Yu, S Liu, Z Wang, YJ Tang, T Chen*. Highly Efficient Hemicellulose Utilization for Acetoin Production by an Engineered Bacillus Subtilis.Journal of Chemical Technology & Biotechnology.2018.

7. Z Cui, Y Mao, Y Zhao, C Chen, Y Tang, T Chen, H Ma*, Z Wang*. Journal of Chemical Technology & Biotechnology.2018

8. KQ Hong, DY Liu, T Chen, ZW Wang*. Recent advances in CRISPR/Cas9 mediated genome editing in Bacillus subtilis. World Journal of Microbiology and Biotechnology 34 (10), 153.


1.Y Mao, J Fu, R Tao, C Huang, Z Wang*, YJ Tang, T Chen*, X Zhao. Systematic metabolic engineering of Corynebacterium glutamicum for industrial-level production of optically pure D-(-)-Acetoin. Green Chemistry,2017,19, 5691-5702.

2. G Huo, Y Zhu, Q Liu, R Tao, N Diao, Z Wang, T Chen*. Metabolic engineering of an E. coli ndh knockout strain for PHB production from mixed glucose‐xylose feedstock.Journal of Chemical Technology and Biotechnology.2017, 92(10):2739-2745.

3.Q Yuan, T Huang, P Li, T Hao, F Li, H Ma*, Z Wang*, X Zhao, T Chen*, I. Goryanin. Pathway-Consensus Approach to Metabolic Network Reconstruction for Pseudomonas putida KT2440 by Systematic Comparison of Published Models. PloS one,2017, 12 (1), e0169437.

4. Y Zhang, P Kang, S Liu, Y Zhao, Z Wang, T Chen*. glyA gene knock-out in Escherichia coli enhances L-serine production without glycine addition., Biotechnology and Bioprocess Engineering. 2017, 22 (4), 390-396.

5. T Liu, YY Yu, T Chen, WN Chen. A synthetic microbial consortium of shewanella and bacillus for enhanced generation of bioelectricity. Biotechnology and bioengineering.2017, 114 (3), 526-532.

6. Z Li, J Meng, W Wang, Z Wang, M Li, T Chen, CJ Liu. The room temperature electron reduction for the preparation of silver nanoparticles on cotton with high antimicrobial activity. Carbohydrate Polymers.2017, 161, 270-276.

7.Y Zou, T Chen, L Feng, S Zhang, D Xing, Z Wang*. Enhancement of 5-aminolevulinic acid production by metabolic engineering of the glycine biosynthesis pathway in Corynebacterium glutamicum. Biotechnology Letters, 2017, 39(9):1369-1374.

8. A Kalantari, T Chen, B Ji, IA Stancik, V Ravikumar, D Franjevic, C. Saulou-Bérion, A. Goelzer, and Ivan Mijakovic..Conversion of glycerol to 3-hydroxypropanoic acid by genetically engineered Bacillus subtilis. Frontiers in microbiology.2017, 8:638.


1.J Fu, G Huo, L Feng, Y Mao, Z Wang*, H Ma, T Chen*, X Zhao. Metabolic engineering of Bacillus subtilis for chiral pure meso-2, 3-butanediol production. Biotechnology for biofuels. 2016.9:90

2.Lili Feng, Ya Zhang, Jing Fu, Tao Chen, Xueming Zhao, Zhiwen Wang*, Metabolic engineering of Corynebacterium glutamicum for efficient production of 5-aminolevulinic acid. Biotechnology and Bioengineering.2016.113(6):1284-1293.

3.Y Li, X Zhu, X Zhang, J Fu, Z Wang, T Chen*, X Zhao. Characterization of genome-reduced Bacillus subtilis strains and their application for the production of guanosine and thymidine. Microbial cell factories. 2016.15:94.

4.Bo Zhang, Xin-li Li, Fu Jing, Ning Li, Zhiwen Wang*, Ya-jie Tang, Tao Chen*. Production of Acetoin through Simultaneous Utilization of Glucose, Xylose, and Arabinose by Engineered Bacillus subtilis. PloS one. 2016,11 (7), e0159298.

5.JH Yu, LW Zhu, ST Xia, HM Li, YL Tang, XH Liang, T Chen, YJ Tang*. Combinatorial optimization of CO2 transport and fixation to improve succinate production by promoter engineering. Biotechnology & Bioengineering. 2016,113(7):1531-1541.

6.S Liu, P Kang, Z Cui, Z Wang, T Chen*. Increased riboflavin production by knockout of 6-phosphofructokinase I and blocking the Entner–Doudoroff pathway in Escherichia coli.Biotechnology letters. 2016.38(8):1307-1314.

7. Qinglong Meng, Yanfei Zhang, Xiaozhi Ju, Chunling Ma, Hongwu Ma*, Jiuzhou Chen, Ping Zheng, Jibin Sun, Jun Zhu, Yanhe Ma, Xueming Zhao, Tao Chen*. Production of 5-aminolevulinic acid by cell free multi-enzyme catalysis. Journal of Biotechnology. 2016;226:8–13.

8.Xiaoyan Yang, Qianqian Yuan, Yangyang Zheng, Hongwu Ma*, Tao Chen, Xueming Zhao An engineered non-oxidative glycolysis pathway for acetone production in Escherichia coli. Biotechnology Letters. 2016, 38(8):1359-1365.

9.X Wang, G Wang, X Li, J Fu, T Chen, Z Wang*, X Zhao. Directed evolution of adenylosuccinate synthetase from Bacillus subtilis and its application in metabolic engineering. Journal of biotechnology. 2016. 231:115-121.

10. J Meng, B Wang, D Liu, T Chen, Z Wang*, X Zhao. High-yield anaerobic succinate production by strategically regulating multiple metabolic pathways based on stoichiometric maximum in Escherichia coli. Microbial Cell Factories. 2016;15:141.

11.余君涵, 马雯雯, 王智文*,陈涛, 赵学明. 人工合成启动子文库研究进展. 微生物学通报. 2016;43(1):198-204.

12.徐志博, 林振泉, 陈涛*. 大肠杆菌中核黄素的生物合成途径改造及生产. 化学工业与工程. 2016;33(2):114-119.


1.Yifan Li; Zhenquan Lin; Can Huang; Yan Zhang; Zhiwen Wang; Chen Tao*, Xueming Zhao.  Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing. Metabolic Engineering. 2015,31:13-21.27. 

2. Zhang, Bo;   Li, Ning;   Wang, Zhiwen;   Tang, Ya-Jie;   Chen, Tao*   Zhao, Xueming, Inverse metabolic engineering of Bacillus subtilis for xylose utilization based on adaptive evolution and whole-genome sequencing, Applied Microbiology and Biotechnology, 99(2), pp 885-896, 2015/2/1.

3.Wang Xiaoyue, Wang Baiyun, Wang Zhiwen*, Chen Tao, Zhao Xueming. The research progress of protein directed evolution. Prog. Biochem. Biophys. 2015,42(2):123-131.

4.Ma, Wenwen;  Wang, Xiaoyue;  Mao, Yufeng;  Wang, Zhiwen*;  Chen, Tao;  Zhao, Xueming, Development of a markerless gene replacement system in Corynebacterium glutamicum  using upp as a counter-selection marker., Biotechnology Letters,.  2015.37(3):609-617.

5.Zhibo Xu, Zhenquan Lin, ZhiwenWang, Tao Chen*. Improvement of the riboflavin production by engineering the precursors biosynthesis pathways in Escherichia coli. Chinese Journal of Chemical Engineering. 2015,23(11):1834-1839.

6.Zhenquan Lin, Yan Zhang, Qianqian Yuan,, Qiaojie Liu, Yifan Li, Zhiwen Wang, Hongwu Ma*, Tao Chen*, Xueming Zhao. Metabolic engineering of Escherichia coli for poly(3-hydroxybutyrate) production via threonine bypass.Microbial Cell Factories,2015,14:185. 

7.Qinglong Meng, Yanfei Zhang, Chunling Ma, Hongwu Ma*, Xueming Zhao, Tao Chen. Purification and functional characterization of thermostable 5-aminolevulinic acid synthases. Biotechnology Letters,2015, 37(11):2247-2253.

8.王永成, 陈涛, 石婷, 王智文*, 赵学明. 嘌呤核苷及其衍生物的代谢工程, 中国生物工程杂志,2015,35(5):87-95.

9.刘晓霏,付晶,霍广鑫,章博,王智文,陈涛*,生物法制备平台化合物乙偶姻的最新研究进展, 中国生物工程杂志,2015,35(10):91-99. 

10.朱旭军, 李一凡, 李杨, 付晶, 王智文, 陈涛*. 陈涛枯草芽孢杆菌无标记遗传操作技术研究进展2015, 42(12): 2440−2447.

11. 李思梦;李晓静;陈涛*, 代谢工程方法改造大肠杆菌生产胸苷, 生物工程学报, 31:01期, pp 105-114, 2015.



1 Qiaojie Liu;   Zhenquan Lin;   Yan Zhang;   Yifan Li;   Zhiwen Wang;   Tao Chen*, Improved poly(3-hydroxybutyrate) production in Escherichia coli by inactivation      of cytochrome bd-II oxidase or/and NDH-II dehydrogenase in low efficient      respiratory chains., Journal of Biotechnology, 192 Pt A卷, pp 170-176, 2014/12/20. 

2. Yan Zhang,Zhenquan Lin,Qiaojie Liu,Yifan Li,Zhiwen Wang,Hongwu Ma,Tao Chen*,Xueming Zhao. Engineering of Serine-Deamination pathway, Entner-Doudoroff pathway and pyruvate dehydrogenase complex to improve poly(3-hydroxybutyrate) production in Escherichia coli. Microbial Cell Factories.2014, 13(1):172.  

3 Ning Li;   Bo Zhang;   Zhiwen Wang;   Ya-Jie Tang;   Tao Chen*;   Xueming Zhao, Engineering Escherichia coli for fumaric acid production from glycerol., Bioresour Technol, 174C卷, pp 81-87, 2014/10/7. 

4. Fu, Jing;  Wang, Zhiwen;  Chen, Tao*;  Liu, Weixi;  Shi, Ting;  Wang, Guanglu;  Tang, Ya-jie;  Zhao, Xueming, NADH plays the vital role for chiral pure D-(-)-2,3-butanediol production in      Bacillus subtilis under limited oxygen conditions., Biotechnology and Bioengineering, 111(10), pp 2126-2131, 2014/10. 

5. Ma, Xianghui;  Zhang, Xinbo;  Wang, Baiyun;  Mao, Yufeng;  Wang, Zhiwen*;  Chen, Tao*;  Zhao, Xueming, Engineering microorganisms based on molecular evolutionary analysis: a succinate       production case study., Evolutionary Applications, 7(8), pp 913-920, 2014/9. 

6. Wang Baiyun;   Wang Xiaoyue;   Wang Zhiwen*;   Chen Tao;   Zhao Xueming, Redox Cofactor Metabolic Engineering with Escherichia coli, Progress in Chemistry, 26(9), pp 1609-1618, 2014/9. 

7. Lin, Zhenquan;   Xu, Zhibo;   Li, Yifan;   Wang, Zhiwen*;   Chen, Tao*;   Zhao, Xueming, Metabolic engineering of Escherichia coli for the production of riboflavin, Microbial Cell Factories, 13卷, 2014/7/16. 2014,13:104 

8. Shi, Ting;   Wang, Yongcheng;   Wang, Zhiwen*;   Wang, Guanglu;   Liu, Dingyu;   Fu, Jing;   Chen, Tao;   Zhao, Xueming, Deregulation of purine pathway in Bacillus subtilis and its use in riboflavin biosynthesis, Microbial Cell Factories, 13:101, 2014/7/15. 

9.Wang, Guanglu;  Bai, Ling;  Wang, Zhiwen*;  Shi, Ting;  Chen, Tao;  Zhao, Xueming, Enhancement of riboflavin production by deregulating gluconeogenesis in Bacillus       subtilis., World Journal of Microbiology and Biotechnology, 30(6), pp 1893-1900, 2014/6. 

10.贾慧慧;李晓静;陈涛*;赵学明, 微生物发酵法生产L-丝氨酸及L-半胱氨酸研究进展, 中国生物工程杂志, 05期, pp 100-106, 2014/5/15. 

11. Yang, Jiangang;  Wang, Zhiwen;  Zhu, Nianqing;  Wang, Baiyun;  Chen, Tao*;  Zhao, Xueming, Metabolic engineering of Escherichia coli and in silico comparing of carboxylation pathways for high succinate productivity under aerobic conditions, Microbiological Research, 169(5–6), pp 432-440, 2014/5. 

12.马红武;刘会娟;朱年青;陈涛*, 代谢工程方法改造谷氨酸棒状杆菌生产乙偶姻, 天津大学学报(自然科学与工程技术版), 11期, pp 967-972, 2014/4. 

13. Zhu, Nianqing;  Xia, Huihua;  Yang, Jiangang;  Zhao, Xueming;  Chen, Tao*, Improved succinate production in Corynebacterium glutamicum by engineering glyoxylate pathway and succinate export system, Biotechnology Letters, 36(3), pp 553-560, 2014/3. 

14. 李桂莹;张新波;王智文*;石婷;陈涛;赵学明, 逆向代谢工程的最新研究进展, 生物工程学报, 08期, pp 1151-1163, 2014/3. 

15. Tao Chen;  Nianqing Zhu;  Huihua Xia, Aerobic production of succinate from arabinose by metabolically engineered Corynebacterium glutamicum, Bioresource Technology, 151(5–6), pp 411-414, 2014/1. 

16. 夏慧华;尹国民;朱年青;陈涛*, 谷氨酸棒杆菌生产琥珀酸的代谢工程研究进展, 微生物学通报, 05期, pp 943-949, 2014


1.Hao, Tong;Han, Binbin;Ma, Hongwu;Fu, Jing;Wang, Hui;Wang, Zhiwen;Tang, Bincai; Chen, Tao*;Zhao, Xueming*, 2013, In silico metabolic engineering of Bacillus subtilis for improved production of riboflavin, Egl-237, (R,R)-2,3-butanediol and isobutanol, Molecular Biosystems, 9(8), pp 2034-2044 (SCI, IF=3.350(2012))

2.Zhu, Nianqing;Xia, Huihua;Wang, Zhiwen;Zhao, Xueming;Chen, Tao*, 2013, Engineering of Acetate Recycling and Citrate Synthase to Improve Aerobic Succinate Production in Corynebacterium glutamicum, PLos One, 8(4), (SCI, IF=3.730(2012) 

3.刘维喜;付晶;章博;陈涛*, 2013, 微生物木糖代谢途径改造制备生物基化学品, 生物工程学报, (08), pp 1161-1172

4.郑宗宝;赵美娜;陈涛*;赵学明, 2013, 基于重组策略的一体化生物加工过程最新进展, 生物工程学报, (10), pp 1354-1362

5.顾群;李一凡;陈涛*, 2013, 合成生物系统的组合优化, 生物工程学报, (08), pp 1064-1074

6.汤彬彩;郝彤;袁倩倩;陈涛;马红武*, 2013, 一种基于代谢网络分析最小化基因组的方法及其在大肠杆菌中的应用, 生物工程学报, (08), pp 1173-1184

7.Li, Yifan;Gu, Qun;Lin, Zhenquan;Wang, Zhiwen;Chen, Tao*;Zhao, Xueming, 2013, Multiplex Iterative Plasnnid Engineering for Combinatorial Optimization of Metabolic Pathways and Diversification of Protein Coding Sequences, ACS Synthetic Biology, 2(11), pp 651-661 (SCI, IF=(2012))

8.Li-Wen Zhu;Xiao-Hong Li;Lei Zhang;Hong-Mei Li;Jian-Hua Liu;Zhan-Peng Yuan;Tao Chen;Ya-Jie Tang*, 2013, Activation of glyoxylate pathway without the activation of its related gene in succinate-producing engineered Escherichia coli, Metabolic Engineering, 20(4), pp 9-19 (EI, SCI, IF=6.859(2012))

9.Shi, Ting;Wang, Guanglu;Wang, Zhiwen*;Fu, Jing;Chen, Tao;Zhao, Xueming, 2013, Establishment of a Markerless Mutation Delivery System in Bacillus subtilis Stimulated by a Double-Strand Break in the Chromosome, PLos One, 8(11), (SCI, IF=3.730(2012))

10.Li, Ning;Zhang, Bo;Chen, Tao*;Wang, Zhiwen;Tang, Ya-jie;Zhao, Xueming, 2013, Directed pathway evolution of the glyoxylate shunt in Escherichia coli for improved aerobic succinate production from glycerol, Journal of Industrial Microbiology and Biotechnology, 40(12), pp 1461-1475 (SCI, IF=2.321(2012))

11.Liu, Rui-Sang; Zhou, Huan;Li, Hong-Mei;Yuan, Zhan-Peng;Chen, Tao;Tang, Ya-Jie*, 2013, Metabolism of L-methionine linked to the biosynthesis of volatile organic sulfur-containing compounds during the submerged fermentation of Tuber melanosporum, Applied Microbiology and Biotechnology, 97(23), pp 9981-9992 (EI, SCI, IF=3.689(2012))

12.Tao Chen*;Weixi Liu;Jing Fu;Bo Zhang;Ya-jie Tang, 2013, Engineering Bacillus subtilis for acetoin production from glucose and xylose mixtures, Journal of Biotechnology, 168(4), pp 499-505 (EI, SCI, IF=3.183(2012))


1.Zheng, Zongbao; Chen, Tao*;Zhao, Meina;Wang, Zhiwen;Zhao, Xueming, 2012, Engineering Escherichia coli for succinate production from hemicellulose via consolidated bioprocessing, Microbial Cell Factories, 11, (EI, SCI, IF=3.5520(2011),

2.Wang, Qingzhao;Chen, Tao; Zhao, Xueming;Chamu, Jauhleene, 2012, Metabolic engineering of thermophilic Bacillus licheniformis for chiral pure D-2,3-butanediol production, Biotechnology and Bioengineering, 109(7), pp 1610-1621 (SCI, IF=3.9460(2011)

3.Wang, Meng;Fu, Jing; Zhang, Xueyu;Chen, Tao*, 2012, Metabolic engineering of Bacillus subtilis for enhanced production of acetoin, Biotechnology Letters, 34(10), pp 1877-1885 (EI, SCI, IF=1.853(2012)

4.付晶;王萌;刘维喜;陈涛*;FuJingWangMengLiuWeixiChenTao(KeyLaborato, 2012, Latest Advances of Microbial Production of 2,3-Butanediol, Progress in Chemistry, 24(11), pp 2268-2276 (SCI, IF=0.670(2012))


1.陈涛,赵学明 译,《生物过程过程:基本概念》,化学工业出版社,北京,2008.

2.Shi Shuobo, Shen Zuo, Chen Xun, Chen Tao*, Zhao Xueming. Increased production of riboflavin by metabolic engineering of the purine pathway in Bacillus subtilis, Biochemical Engineering Journal. 2009,46:28-33.

3.Shi Shuobo, Chen Tao(共同1作), Chen Xun, Zhao Xueming*. Transcriptome analysis guided metabolic engineering of Bacillus subtilis for riboflavin production, Metabolic Engineering, 2009,11:243-252. (EI, SCI, IF=6.859(2012))


5.Duan Yunxia, Chen Tao*, Chen Xun, Wang Jingyu, Zhao Xueming, Enhanced riboflavin production by expressing heterologous riboflavin operon from B. cereus ATCC14579 in Bacillus subtilis. Chinese Journal of Chemical Engineering. 2010,18 (1): 129-136.

6.Wang Zhiwen, Ma XiangHui, Chen Xun, Zhao Xueming, Chen Tao*. Current method and advances in microbial metabolomics. Progress in Chemistry. 2010,22 (1): 163-172.

7.Zhiwen Wang, Tao Chen*, Xianghui Ma, Zhuo Shen, Xueming Zhao. Enhancement of riboflavin production with Bacillus subtilis by expression and site-directed mutagenesis of zwf and gnd gene from Corynebacterium glutamicum. Bioresource Technology. 2011, 102(4):3934-3940.

8.赵学明, 陈 涛. 合成生物学: 进展和展望,《2011年科学发展报告》, 2011,P14-27. 科学出版社.