SCHOOL OF CHEMICAL ENGINEERING AND TECHNOLOGY, TIANJIN UNIVERSITY

Jianping Wen

School of Chemical Engeering and Technology, Tianjin University;

Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University;

SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University;

92 Weijin Road, Nankai District, Tianjin 300072, P. R. China;

TEL: +86(0)22 27892061,  FAX: +86(0)22 27892061,  E-mail: jpwen@tju.edu.cn

1. Educations

09/1985 ~ 07/1989 School of Chemical Engeering and Technology, Tianjin University, Bachelor of Engineering;

09/1989 ~ 07/1992 School of Chemical Engeering and Technology, Tianjin University, Master of Engineering;

09/1992 ~ 07/1995 School of Chemical Engeering and Technology, Tianjin University, PhD. of Engineering.

2. Professional Experience

Professor [06/2003 ~ now], School of Chemical Engeering and Technology, Tianjin University

Assistant Professor [10/1997 ~ 06/2003], School of Chemical Engeering and Technology, Tianjin University

Postdoctoral Researcher [10/1995 ~ 10/1997], School of Chemical Engeering and Technology, Tianjin University

3. Awards and Honors

New Century Excellent Talents in University;

Fermentation optimization technology and application based on System Engineering, The Third Award for Science & technology Development/Achievement of Tianjin (The Six complete people), 2013;

Treatment of Industrial Ammonia-containing waste water with Air-lift Loop Reactor, The Third Award for Science & technology Development/Achievement of Tianjin (The First complete people), 2005;

The new synthesis technology of acetamiprid, The Second Award for Science & technology Development / Achievement of Tianjin (The First complete people), 2002;

4. Research Interests

Technology of biological pharmacy; Technology of biological Energy; Environmental Biotechnology

5. Publications (01/2011-now)

[1] Liang Wei, Jiao Liu, Haishan Qi, Jianping Wen*. Engineering Scheffersomyces stipitis for fumaric acid production from xylose. Bioresource technology. 2015.187:246-254. (IF=5.039 )

[2] Guanyi Wang, Di Huang, Yong Li, Jianping Wen*, Xiaoqiang Jia. A metabolic-based approach to improve xylose utilization for fumaric acid production from acid pretreated wheat bran by Rhizopus oryzae. Bioresource technology. 2015. 180:119-127. (IF=5.039 )

[3] Baohua Wang, Jiao Liu, Huanhuan Liu, Di Huang, Jianping Wen*. Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus. J Ind Microbiol Biotechnol. 2015.42(6): 949-963. (IF= 2.505)

[4] Xing Xin, Haishan Qi, Jianping Wen*, Xiaoqiang Jia, Yunlin Chen. Reduction of foaming and enhancement of ascomycin production in rational Streptomyces hygroscopicus fermentation. Chinese Journal of Chemical Engineering. 2015. Doi: 10.1016/j.cjche.2014.04.006 . (IF= 0.872 )

[5] Haishan Qi, SuMin Zhao, Hong Fu, JianPing Wen*, Xiaoqiang Jia. Coupled cell morphology investigation and metabolomics analysis improves rapamycin production in Streptomyces hygroscopicus. BIOCHEMICAL ENGINEERING JOURNAL. 2014. 91:186-195. (IF= 2.368)

[6] Xinrong Pan, LI Mu, Jianping Wen*, Xiaoqiang Jia. Comparative Metabolomic-Based Metabolic Mechanism Hypothesis for Microbial Mixed Cultures Utilizing Cane Molasses Wastewater for Higher 2-Phenylethanol Production, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2014. 62(40):9927-9935. (IF=3.107 )

[7] Haishan Qi, Sumin Zhao, Hong Fu, Jianping Wen*, Xiaoqiang Jia. Enhancement of ascomycin production in Streptomyces hygroscopicus var. ascomyceticus by combining resin HP20 addition and metabolic profiling analysis, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY. 2014. 41(9): 1365-1374. (IF= 2.505)

[8] Haishan Qi, Shanshan Li, Sumin Zhao, DI Huang, Menglei Xia, Jianping Wen*. Model-Driven Redox Pathway Manipulation for Improved Isobutanol Production in Bacillus subtilis Complemented with Experimental Validation and Metabolic Profiling Analysis, Plos one. 2014. 9(4): e93815. (IF= 3.534)

[9] Haishan Qi, Sumin Zhao, Jianping Wen*, Yunlin Chen, Xiaoqiang Jia. Analysis of ascomycin production enhanced by shikimic acid resistance and addition in Streptomyces hygroscopicus var. ascomyceticus, BIOCHEMICAL ENGINEERING JOURNAL. 2014. 82: 124-133. (IF=2.368 )

[10] Wenjie Du, Di Huang, Menglei Xia, Jianping Wen*, Ming Huang. Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY. 2014. 41(7): 1131-1143. (IF= 2.505)

[11] Menglei Xia, Di Huang, Shanshan Li, Jianping Wen*, Xiaoqiang Jia, Yunlin Chen. Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis. Biotechnology and Bioengineering. 2013, 110 (10): 2717-2730. (IF: 4.164)

[12] Guanyi Wang, Di Huang, Haishan Qi, Jianping Wen*, Xiaoqiang Jia. Rational medium optimization based on comparative metabolic profiling analysis to improve fumaric acid production. Bioresource Technology, 2013, 137:1-8. (IF: 5.039)

[13] Di Huang, Shanshan Li, Menglei Xia, Jianping Wen*, Xiaoqiang Jia. Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement. Microbial Cell Factories, 2013, 12:52. (IF: 4.25)

[14] Sumin Zhao, Di Huang, Haishan Qi, Jianping Wen*, Xiaoqiang Jia. Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus. Applied Microbiology and Biotechnology. 2013, 97:5329-41.( IF: 3.811)

[15] Di Huang, Menglei Xia, Shanshan Li, Jianping Wen*, Xiaoqiang Jia. Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies. Journal of Industrial Microbiology & Biotechnology. 2013, 40 (9): 1023-1037. (IF: 2.505)

[16] Li Mu, Jianping Wen*, Robust aptamer sol-gel solid phase microextraction of very polar adenosine from human plasma. Journal of Chromatography A. 2013.1279: 7-12. (IF= 4.258)

[17] Li Mu, Jianping Wen*, Spatial distribution characteristics of polycyclic musks as a chemical marker in river water and sediment compared with other typical pollutants. Water Science and Technology, 2013, 67(6): 1173-1180. (IF= 1.212)

[18] Li Mu, Jianping Wen*, Engineering Bacillus subtilis 168 produces L-malic acid by heterologous biosynthesis pathway construction and lactate dehydrogenase deletion. World Journal of Microbiology & Biotechnology, 2013, 29 (1): 33-41. (IF= 1.353)

[19] Peng Liu, Jianping Wen*, Yunlin Chen, Xiaoqiang Jia, Femtosecond laser-based mutagenesis strategy for micronomicin production enhancement of Micromonospora sagamiensis ATCC 21826. World Journal of Microbiology & Biotechnology, 2013, 29(6):1121-1127. (IF= 1.353)

[20] Di Huang, Jianping Wen*, Guoying Wang, Guanghai Yu, Xiaoqiang Jia and Yunlin Chen ，In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement，applied microbiology and biotechnology, Applied Microbiology and Biotechnology. 2012, 94: 637-649.（IF: 3.811）

[21] Shouzhi Yu, Di Huang, Wen Jianping*, Shuang Li, Yunli Chen, Xiaoqiang Jia. Metabolic profiling of a Rhizopus oryzae fumaric acid production mutant generated by femtosecond laser irradiation, Bioresource Technology, 2012, 114:610-615.（IF: 5.039）

[22] Shanshan Li, Xiaoqiang Jia, Jianping Wen*, Improved 2-methyl-1-propanol production in an engineered Bacillus subtilis by constructing inducible pathways, Biotechnology Letters, 2012, 34 (12):2253-2258. (IF: 1.736)

[23] Shanshan Li, Di Huang, Yong Li, Jianping Wen*, Xiaoqiang Jia, Rational improvement of the engineered isobutanol-producing Bacillus subtilis by elementary mode analysis, Microbial Cell Factory, 2012, 11:101.（IF: 4.25）

[24] Hai-shan Qi, Xing Xin, Shan-shan Li, Jianping Wen*, Yun-lin Chen, and Xiao-qiang Jia. Higher-level production of ascomycin (FK520) by Streptomyces hygroscopicus var. ascomyceticus irradiated by femtosecond laser, Biotechnology and Bioprocess Engineering, 2012, 17 (4): 770-779.（IF: 1.22）

[25] Xue Wang, Xiaoqiang Jia, Jianping Wen*, Transient CFD modeling of toluene waste gas biodegradation in a gas-liquid-solid three-phase airlift loop reactor by immobilized Pseudomonas putida, Chemical Engineering Journal, 2011, 172(2-3): 735-745. （IF: 4.058）

[26] Huang Di, Jia Xiaoqiang, Wen Jianping*, Wang Guoying, Yu Guanghai, Caiyin Qinggele，Chen Yunlin, Metabolic flux analysis and principal nodes identification for daptomycin production improvement by Streptomyces roseosporus in batch culture, Applied Biochemistry and Biotechnology, 2011, 165(7-8): 1725-1739. （IF: 1.687）

[27] Shanshan Li, Jianping Wen*, Xiaoqiang Jia. Engineering Bacillus subtilis for isobutanol production by heterologous Ehrlich pathway construction and α-ketoisovalerate precursor overexpression, Applied Microbiology and Biotechnology, 2011, 91(3): 577-589. （IF: 3.811）

[28] Xiaoqiang Jia, Shanshan Li, Sha Xie, Jianping Wen*, Engineering a metabolic pathway for isobutanol biosynthesis in Bacillus subtilis, Applied Biochemistry and Biotechnology, 2011, 168(1): 1-9. (IF: 1.687)

[29] Chunsheng Qiu, Xiaoqiang Jia, Jianping Wen*, Purification of high strength wastewater originated from bioethanol production with simultaneous biogas production, World Journal of Microbiology & Biotechnology, 2011, 27(11): 2711-2722. （IF: 1.353）

[30] Chunsheng Qiu, Jianping Wen*, Xiaoqiang Jia, Extreme-thermophilic biohydrogen production from lignocellulosic bioethanol distillery wastewater with community analysis of hydrogen-producing microflora, International Journal of Hydrogen Energy, 2011, 36(14): 8243-8251. （IF: 2.93）

[31] Guanghai Yu, Xiaoqiang Jia, Jianping Wen*, Wenyu Lu, Guoying Wang, Qinggele Caiyin, Yunlin Chen. Enhancement of daptomycin production in Streptomyces roseosporus LC-51 by manipulation of cofactors of enzymes, World Journal of Microbiology and Biotechnology, 2011, 27(8): 2685-2691. （IF: 1.353）

[32] Guanghai Yu, Xiaoqiang Jia, Jianping Wen*, Wenyu Lu, Guoying Wang, Qinggele Caiyin, Yunlin Chen. Strain Improvement of Streptomyces roseosporus for daptomycin production by rational screening of He-Ne laser and NTG induced mutants and kinetic modeling. Applied Biochemistry and Biotechnology, 2011, 163(6): 729-743. （IF: 1.687）

[33] Xiaoqiang Jia, Jianping Wen*, Tao Ji, Yan Jiang. Modeling of phenol biodegradation by Candida tropicalis immobilized in alginate gel beads, The Canadian Journal of Chemical Engineering, 2011, 89(6): 1566-1574. （IF: 1.313）

[34] Xiaoqiang Jia, Peng Liu, Shuang Li, Shanshan Li, Jianping Wen*, D-lactic acid production by a genetically engineered strain Corynebacterium glutamicum, World Journal of Microbiology and Biotechnology, 2011, 27(9): 2117-2124. （IF: 1.353）

[35] Xiaoqiang Jia, Qing Yuan, Jianping Wen*, Wei Feng. Fluid flow modeling of a gas-induced pulsating flow bubble column, Chemical and Biochemical Engineering Quarterly, 2011, 25(1): 27-36. （IF: 0.911）

[36] Wenyu Lu, Jinghua Fan, Jianping Wen*, Zhendong Xia, Qinggele Caiyin. Kinetic analysis and modeling of daptomycin batch fermentation by Streptomyces roseosporus, Applied Biochemistry and Biotechnology, 2011, 163(4): 453-462. （IF: 1.687）