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SCHOOL OF CHEMICAL ENGINEERING AND TECHNOLOGY, TIANJIN UNIVERSITY

Li, Bingzhi
Title: Professor
Address: B902, Tianjinlou, Weijin Road campus, Tianjin University
Office Phone: 022-27402503
Email: bzli@tju.edu.cn


Bing-Zhi Li,  Professor 

Key Laboratory of Systems Bioengineering (Ministry of Education)
School of Chemical Engineering and Technology

SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin),

Tianjin University,

Weijin Road 92, Nankai district,

Tianjin, 300072, PR China

E-mail: bzli@tju.edu.cn

Tel.: 86-13821781519

 

PROFESSIONAL EXPERIENCE

Tianjin University, Tianjin, China

2017.01-: Professor in School of Chemical Engineering and Technology

2014.06-2016.12: Associate Professor in School of Chemical Engineering and Technology

2010.10-2014.06: Lecturer in School of Chemical Engineering and Technology

 EDUCATION

2005.9- 2010.6   Ph.D., Biochemical Engineering, Tianjin University, China

2008.2-2008.8    Visiting scholar, Michigan State University, USA

2001.9-2005.6    B.S., Biological Technology, Nankai University, Tianjin, China

 RESEARCH INTERESTS

  • Lignocellulose conversion: pretreatment, hydrolysis and fermentation
  • Synthetic biology: engineering yeast for xylose utilization and strain tolerance
  • Systems biology: genome analysis of strain tolerance to inhibitors by transcriptome analysis, metabolome analysis and proteome analysis

 AWARDS & HORNORS

  • Changjiang Scholar Program for Young Scholar (2017)
  • National Science Fund for Excellent Young Scholars (2016)
  • Tianjin “Young Talents of Science and Technology” (2016)
  • Outstanding Youth  Award, 2017 Global Chinese Chemical Engineers Symposium (2017)
  • Min Enze Awards for Chemical Engineering on Energy (2015)
  • Tianjin University PeiYang Scholar—Young Key Faculty (2013)
  • Baoshun Award for Faculty in Tianjin University (2013) 
  • International Genetic Engineering Machine (iGEM) Competition, Gold Medal (2015)
  • iGEM, Best Energy Project Award (2015)
  • iGEM, Bronze Medal (2014)
  • iGEM, Gold Medal (2013)
  • iGEM, Best Poster Award (2013)

 

 PUBLICATIONS (*: corresponding author, #: co-first author)

 More than 80 peer-reviewed papers and 40 paptents was published.

<2018年>

41. Zhu JQ, Li WC, Qin L, Zhou X, Chen S, Liu H, Liu ZH, Zhou X, Li X, Li BZ*, Yuan YJ. Stepwise pretreatment of aqueous ammonia and ethylenediamine improveenzymatic hydrolysis of corn stover Industrial Crops & Products. 2018. 124:201–208.

40. Zhu JQ, Wu XL, Li WC, Qin L, Chen S, Xu T, Liu H, Zhou X, Li X, Zhong C, Li BZ*, Yuan YJ. Ethylenediamine pretreatment of corn stover facilitates high gravity fermentation with low enzyme loading. Bioresource Technology. 2018 Jul 7;267:227-234

39. Li WC, Li X, Zhu JQ, Qin L, Li BZ*, Yuan YJ. Improving xylose utilization and ethanol production from dry dilute acid pretreated corn stover by two-step and fed-batch fermentation. Energy. 2018 Aug. 15; 157:877-885.

38. Jia B#, Wu Y#, Li BZ#, Mitchell LA, Liu H, Pan S, Wang J, Zhang HR, Jia N, Li B, Shen M, Xie ZX, Liu D, Cao YX, Li X, Zhou X, Qi H, Boeke JD, Yuan YJ*. Precise control of SCRaMbLE in synthetic haploid and diploid yeast. Nature Communications. 2018 May 22;9(1):1933.

37. Qin L#, Zhao X#, Li WC, Zhu JQ, Liu L, Li BZ*, Yuan YJ. Process analysis and optimization of simultaneous saccharification and co-fermentation of ethylenediamine-pretreated corn stover for ethanol production. Biotechnology for Biofuels. 2018 Apr 23; 11:118.


<2017年>

36. Xie ZX#, Liu D#, Li BZ#, Zhao M, Zeng BX, Wu Y, Shen Y, Lin T, Yang P, Dai J, Cai Y, Yang H, Yuan YJ*. Design and chemical synthesis of eukaryotic chromosomes.Chemical Society Reviews. 2017;46:7191-7207.

35. Wu XL#, Li BZ#, Zhang WZ, Song K, Qi H, Dai JB, Yuan YJ*. Genome-wide landscape of position effects on heterogeneous gene expression in Saccharomyces cerevisiae. Biotechnology for Biofuels. 2017 Jul 18;10:189.

34. Liu H#, Zhu JQ#, Li X#, Li HZ, Qin L, Li H, Wang X, Bai X, Li WC, Li BZ*, Yuan YJ. Hybridization improves inhibitor tolerance of xylose-fermenting Saccharomyces cerevisiae. BioResources. 2017;12 (3): 4737-4753.

33. Zhang W#, LiuH#, LiX#, Liu D, Dong XT, Li FF, Wang EX, Li BZ*, Yuan YJ. Production of naringenin from D-xylose with co-culture of E. coli and S. cerevisiae. Engineering in Life Sciences. 2017. Sept, 9; 17(9):1021–1029.

32. Qin L, Li X, Zhu JQ, Li WC, Xu H, Guan QM, Zhang MT, Li BZ*, Yuan YJ.Optimization of ethylenediamine pretreatment and enzymatic hydrolysis to produce fermentable sugars from corn stover. Industrial Crops and Products. 2017 August; 102:51-57.

31．Liu GG, Li BZ*, Li C, Yuan YJ. Enhancement of Simultaneous Xylose and Glucose Utilization by Regulating ZWF1 and PGI1 in Saccharomyces cerevisiae. Transactions of Tianjin University. 2017 May 17; 23(2):201-210.

30. Liu D#, Li BZ#, Liu H, Guo XJ, Yuan YJ*. Profiling influences of gene overexpression on heterologous resveratrol production in Saccharomyces cerevisiae. Frontiers in Chemical Science and Engineering. 2017Mar 20; 11(1): 117-125.

29. Wu Y#, Li BZ#, Zhao M, Mitchell LA, Xie ZX, Lin QH, Wang X, Xiao WH, Wang Y, Zhou X, Liu H, Li X, Ding MZ, Liu D, Zhang L, Liu BL, Wu XL, Li FF, Dong XT, Jia B, Zhang WZ, Jiang GZ, Liu Y, Bai X, Song TQ, Chen Y, Zhou SJ, Zhu RY, Gao F, Kuang Z, Wang X, Shen M, Yang K, Stracquadanio G, Richardson SM, Lin Y, Wang L, Walker R, Luo Y, Ma PS, Yang H, Cai Y, Dai J, Bader JS, Boeke JD, Yuan YJ*. Bug mapping and fitness testing of chemically synthesized chromosome X. Science. 2017Mar 10; 355(6329).pii: eaaf4706.

28. Xie ZX#, Li BZ#, Mitchell LA, Wu Y, Qi X, Jin Z, Jia B, Wang X, Zeng BX, Liu HM, Wu XL, Feng Q, Zhang WZ, Liu W, Ding MZ, Li X, Zhao GR, Qiao JJ, Cheng JS, Zhao M, Kuang Z, Wang X, Martin JA, Stracquadanio G, Yang K, Bai X, Zhao J, Hu ML, Lin QH, Zhang WQ, Shen MH, Chen S, Su W, Wang EX, Guo R, Zhai F, Guo XJ, Du HX, Zhu JQ, Song TQ, Dai JJ, Li FF, Jiang GZ, Han SL, Liu SY, Yu ZC, Yang XN, Chen K, Hu C, Li DS, Jia N, Liu Y, Wang LT, Wang S, Wei XT, Fu MQ, Qu LM, Xin SY, Liu T, Tian KR, Li XN, Zhang JH, Song LX, Liu JG, Lv JF, Xu H, Tao R, Wang Y, Zhang TT, Deng YX, Wang YR, Li T, Ye GX, Xu XR, Xia ZB, Zhang W, Yang SL, Liu YL, Ding WQ, Liu ZN, Zhu JQ, Liu NZ, Walker R, Luo Y, Wang Y, Shen Y, Yang H, Cai Y, Ma PS, Zhang CT, Bader JS, Boeke JD, Yuan YJ*. “Perfect” designer chromosome V and behavior of a ring derivative. Science. 2017Mar 10; 355(6329). pii: eaaf4704.

27. Qin L#, Li X#, Liu L, Zhu JQ, Guan QM, Zhang MT, Li WC, Li BZ*, Yuan YJ. Dual effect of soluble materials in pretreated lignocellulose on simultaneous saccharification and co-fermentation process for the bioethanol production.Bioresource Technology. 2017 Jan;224:342-348.

26. Li WC#, Li X#, Qin L, Zhu JQ, Han X, Li BZ*, Yuan YJ. Reducing sugar loss in enzymatic hydrolysis of ethylenediamine pretreated corn stover. Bioresource Technology. 2017 Jan;224:405-410.


<2016年>

25. Zhu JQ#, Li X#, Qin L, Li WC, Li HZ, Li BZ*, Yuan YJ. In situ detoxification of dry dilute acid pretreated corn stover by co-culture of xylose-utilizing and inhibitor-tolerant Saccharomyces cerevisiae increases ethanol production. Bioresource Technology. 2016 Oct;218:380-7.

24. Qin L, Liu L, Li WC, Zhu JQ, Li X, Li BZ*, Yuan YJ.Inhibition of lignin-derived phenolic compounds to cellulase. Biotechnology for Biofuels. 2016Mar 22;9:70.

23. Qin L, Liu L, Li WC, Zhu JQ, Li BZ*, Yuan YJ. Evaluation of soluble fraction and enzymatic residual fraction of dilute dry acid, ethylenediamine, and steam explosion pretreated corn stover on the enzymatic hydrolysis of cellulose. Bioresource Technology. 2016 Mar 4;209:172-179.

22. Hu ML, Zha J, He LW, Lv YJ, Shen MH, Zhong C, Li BZ*, Yuan YJ. Enhanced bioconversion of cellobiose by industrial Saccharomyces cerevisiae used for cellulose utilization. Frontiers in Microbiology. 2016 Feb 15;7:241.


<2015年>

21. Qin L, Li WC, Zhu JQ, Liang JN, Li BZ*, Yuan YJ. Ethylenediamine pretreatment changes cellulose allomorph and lignin structure of lignocellulose at ambient pressure. Biotechnology for Biofuels. 2015 Oct 29;8:174.

20. Qi X#, Zha J#, Liu GG, Zhang W, Li BZ*, Yuan YJ. Heterologous xylose isomerase pathway and evolutionary engineering improve xylose utilization in Saccharomyces cerevisiae. Frontiers in Microbiology. 2015. Oct 8; 6:1165.

19. Wang X, Bai X, Chen DF, Chen FZ,Li BZ*, Yuan YJ. Increasing proline and myo-inositol improves tolerance of Saccharomyces cerevisiae to the mixture of multiple lignocellulose-derived inhibitors. Biotechnology for Biofuels. 2015. Sep 15. 8:142.

18. Zhu JQ, Qin L, Li WC, Zhang J, Bao J, Huang YD, Li BZ*, Yuan YJ.Simultaneous saccharification and co-fermentation of dry diluted acid pretreated corn stover at high dry matter loading: overcoming the inhibitors by non-tolerant yeast. Bioresource Technology. 2015 Sep 6;198:39-46.

17. Luo Y#, Li BZ#, Liu D#, Zhang L, Chen Y, Jia B, Zeng BX, Zhao H, Yuan YJ*. Engineered biosynthesis of natural products in heterologous hosts. Chemical Society Reviews. 2015 Aug 7;44(15):5265-5290.

16. Qi H#, Li BZ#, ZhangWQ, Liu D, Yuan YJ*. Modularization of genetic elements promotes synthetic metabolic engineering.Biotechnology Advances. 2015 Nov 15;33(7):1412-9.

15. Shen MH, Song H, Li BZ*, Yuan YJ. Deletion of D-ribulose-5-phosphate 3-epimerase (RPE1) induces simultaneous utilization of xylose and glucose in xylose-utilizing Saccharomyces cerevisiae. Biotechnology Letters. 2015, 37(5):1031-1036.

14. Liu ZH#, Qin L#,Li BZ*, Yuan YJ.Physical and chemical characterizations of corn stover from leading pretreatment methods and the effects on enzymatic hydrolysis. ACS Sustainable Chemistry & Engineering. 2015, 3 (1):140–146. (IDS: AY3XY)


<2014年>

13. Liu ZH, Qin L,Zhu JQ, Li BZ*, Yuan YJ.Simultaneous saccharification and fermentation of steam-exploded corn stover at high glucan loading and high temperature. Biotechnology for Biofuels. 2014 Dec 4; 7:167. (IDS: AZ4UW) (Highly accessed paper)

12. Zhu JQ, Qin L, Li BZ*, Yuan YJ.Simultaneous saccharification and co-fermentation of aqueous ammonia pretreated corn stover with an engineered Saccharomyces cerevisiae SyBE005.Bioresource Technology. 2014 Oct;169:9-18. (IDS: AN8ZH)

11. Lv YJ, Wang X, Ma Q, Bai X, Li BZ*, Yuan YJ. Proteomic analysis reveals complex metabolic regulation in Saccharomyces cerevisiae cells against multiple inhibitors stress. Applied Microbiology and Biotechnology. 2014 Mar;98(5):2207-21. (IDS:AB9JB)

10. Feng L, Qin L, Liu ZH, Dong CY, Li BZ*, Yuan YJ. Combined severity during pretreatment chemical and temperature on the saccharification of wheat straw using acids and alkalis of differing strength. BioResources. 2014, 9(1):24-38.(IDS:AB7UO)

9. Wang X, Jin M*, Balan V, Jones AD, Li Xia, Li BZ*, Dale BE, Yuan YJ. Comparative metabolic profiling revealed limitations in xylose-fermenting yeast during co-fermentation of glucose and xylose in the presence of inhibitors. Biotechnology and Bioengineering. 2014, 111:152-164. (IDS: 265VB)


<2013年>

8. Qin L, Liu ZH, Jin MJ, Li BZ*, Yuan YJ.High temperature aqueous ammonia pretreatment and post-washing enhance the high solids enzymatic hydrolysis of corn stover.Bioresource Technology.2013 Oct;146:504-11.(IDS:231TZ)

7. Liu ZH, Qin L, Jin MJ, Pang F, Li BZ*, Kang Y, Dale BE,Yuan YJ.Evaluation of storage methods for the conversion of corn stover biomass to sugars based on steam explosion pretreatment.Bioresource Technology.2013;132:5-15.（IDS:113YZ）(曾入选ESI highly cited paper)

6. Wang X, Li BZ*, Ding MZ, Zhang WW, Yuan YJ. Metabolomic analysis reveals key metabolites related to the rapid adaptation of Saccharomyce cerevisiae to multiple inhibitors of furfural, acetic acid, and phenol. OMICS. 2013 Mar;17(3):150-9.(IDS:107AC)

5. Liu ZH, Qin L, Pang F, Jin MJ, Li BZ*, Kang Y, Dale BE, Yuan YJ. Effects of biomass particle size on steam explosion pretreatment performance forimproving the enzyme digestibility of corn stover. Industrial Crops and Products. 2013; 44:176-184.（IDS:099XO）(ESI highly cited paper)


<2010年>

4. Li BZ, Cheng JS, Ding MZ, Yuan YJ*. Transcriptomeanalysisofdifferentialresponsesofdiploidandhaploidyeasttoethanolstress. Journal of Biotechnology. 2010 Aug; 148(4):194-203. (IDS: 639KA)

3. Li BZ, Yuan YJ*. Transcriptome shifts in response to furfural and acetic acid in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology. 2010 May; 86(6):1915-24. (IDS: 587BD)

2. Li BZ, Cheng JS, Qiao B, Yuan YJ*. Genome-wide transcriptional analysis of Saccharomyces cerevisiae during industrial bioethanol fermentation. Journal of Industrial Microbiology and Biotechnology. 2010 Jan; 37:43-55. (IDS: 536GS)

1. Li BZ, Balan V*, Yuan YJ*, Dale BE. Process optimization to convert forage and sweet sorghum bagasse to ethanol based on ammonia fiber expansion (AFEX) pretreatment. Bioresource Technology. 2010 Feb; 101(4):1285-92. (IDS: 523KJ)