师资力量
- 姓名：卢文玉
- 现任职称/职务：教授/博导
- 通讯地址：天津大学北洋园校区54-226
- 电子邮箱：wenyulu@tju.edu.cn
- 办公电话：wenyulu@tju.edu.cn
论著专利
在Metabolic Engineering、Biotechnology and Bioengineering、AIChE Journal等主流期刊发表学术论文100余篇，授权发明专利18项，参编教材2部。
部分SCI收录论文如下：
2025：
Ge Weiwei, Zhang Jiale, Zhang Chuanbo*, Lu Wenyu*. Construction of isopentenol utilization pathway and artificial multifunctional enzyme for miltiradiene synthesis in Saccharomyces cerevisiae[J]. Bioresource Technology,2025, 419: 1-11.
2024：
Zhang Chuanbo#, Chen Chen#, Bian Xueke#, Zhang Jiale, Zhang, Zhanwei, Ma, Yuanyuan*, Wenyu Lu*. Construction an orthogonal transport system for Saccharomyces cerevisiae peroxisome to efficiently produce sesquiterpene[J]. Metabolic Engineering, 2024, 85:84-93.
Zhang Wanze, Zhang Jiale, Zhao Xiaomeng, Zhang Zhanwei, He Shifan, Bian Xueke, Wang Haibin, Zhang Chuanbo*, Lu Wenyu*. Efficient production of ginsenoside Rh2 from xylose by remodeling metabolism in Saccharomyces cerevisiae[J]. Chemical Engineering Journal, 2024, 494:1-13.
Pai Huihui#, Liu Yiying#, Zhang Chuanbo, Su Jianyu*, Lu Wenyu*. Effects of the pleiotropic regulator DasR on lincomycin production in Streptomyces lincolnensis[J]. Applied Microbiology and Biotechnology, 2024, 108: 373
Tian jinping#, Li Yue#, Zhang Chuanbo, Su Jianyu*, Lu Wenyu*. Characterization of a pleiotropic regulator MtrA in Streptomyces avermitilis controlling avermectin production and morphological differentiation[J]. Microbial cell factories, 2024, 23: 1-14.
Zhang Chuanbo#, Tian Jinping#, Zhang Jiale, Liu Ruixia, Zhao Xiaomeng, Lu Wenyu*. Engineering and transcriptome study of Saccharomyces cerevisiae to produce ginsenoside compound K by glycerol[J]. Biotechnology Journal, 2024, 19(2): 1-11, DOI: 10.1002/biot.202300383.
Wang Haibin, Fu Xiaomeng, Zhang Chuanbo*, Lu Wenyu*.Overproduction of cordycepin in Saccharomyces cerevisiae by cordycepin synthase screening and metabolic engineering[J]. AIChE Journal, 2024, 70(4): 1-13. DOI: 10.1002/aic.18361.
2023：
Fu, Xiaomeng, Zuo Xiaoru, Zhao Xiaomeng, Zhang Huizhi, Zhang Chuanbo*, Lu Wenyu*. Characterization and designing of an SAM riboswitch to establish a high-throughput screening platform for SAM overproduction in Saccharomyces cerevisiae[J]. Biotechnology and Bioengineering, 2023, 120(12): 3622-3637.
Ye Nan, Du Jiaxin, Bian Xueke, Zhao Xiaomeng, Zhang Chuanbo*, Lu Wenyu*. Heterologous synthesis of ginsenoside F2 in Saccharomyces cerevisiae by pathway and UDP-glycosyltransferase engineering[J]. Chemical Engineering Science, 2023, 278: 1-8.
He Shifan, Zhang Zhanwei, Lu Wenyu*. Natural promoters and promoter engineering strategies for metabolic regulation in Saccharomyces cerevisiae[J]. Journal of Industrial Microbiology and Biotechnology, 2023, 50(1): 1-16.
2022：
Fu Xiaomeng, Hong Kunqiang, Wang Haibin, Zhang Chuanbo*, Lu Wenyu*. Screening and remodeling of enone oxidoreductase for high production of 2(or 5)-Ethyl-5(or 2)-methyl-4-hydroxy-3(2H)-Furanone in Saccharomyces Cerevisiae[J]. Journal of Agricultural and Food Chemistry, 2022, 70(32): 9888-9897.
He Shifan, Zhang Zhanwei, Zhang Chuanbo*, Lu Wenyu*. Construction and optimization of malonyl-CoA sensors in Saccharomyces cerevisiae by combining promoter engineering strategies[J]. Processes, 2022, 10(12): 2660-2670.
Ju Haiyan, Zhang Chuanbo, He Shifan, Nan Weihua, Lu Wenyu*. Construction and optimization of Saccharomyces cerevisiae for synthesizing forskolin[J]. Applied Microbiology and Biotechnology, 2022, 106(5-6): 1933-1944.
Tan Jinxiu, Zhang Chuanbo, Pai Huihui, Lu Wenyu*. Heterologous biosynthesis of taraxerol by engineered Saccharomyces cerevisiae[J]. FEMS Microbiology Letters, 2022, 369(1): 1-8.
Wei Panpan, Zhang Chuanbo, Bian Xueke, Lu Wenyu*. Metabolic engineering of Saccharomyces cerevisiae for heterologous carnosic acid production[J]. Frontiers in Bioengineering and Biotechnology, 2022, 10: 1-12.
Zhao Mengya, Zhang Chuanbo, Wang Haibin, He Shifan, Lu Wenyu*. Biosynthesis of valerenic acid by engineered Saccharomyces cerevisiae[J]. Biotechnology Letters, 2022, 44(7): 857-865.
2021：
Ju Haiyan, Zhang Chuanbo, Lu Wenyu*. Progress in heterologous biosynthesis of forskolin[J]. Journal of Industrial Microbiology and Biotechnology, 2021, 48: 1-10.
Li Man, Xu Shuo, Lu Wenyu*. Engineering Corynebacterium glutamicum for geraniol production[J]. Transactions of Tianjin University, 2021, 27(5): 377-384.
Li Man, Zhao Mengya, Wei Panpan, Zhang Chuanbo, Lu Wenyu*. Biosynthesis of soyasapogenol b by engineered Saccharomyces cerevisiae[J]. Applied Biochemistry and Biotechnology, 2021, 193(10): 3202-3213.
Zhao Xiaomeng, Feng Xueke, Ye Nan, Wei Panpan, Zhang Zhanwei, Lu Wenyu*. Protective effects and mechanism of coenzyme Q10 and vitamin C on doxorubicin-induced gastric mucosal injury and effects of intestinal flora[J]. Korean Journal of Physiology & Pharmacology, 2021, 25(4): 261-272.
Zhao Xiaomeng, Ye Nan, Feng Xueke, Ju Haiyan, Liu Ruixia, Lu Wenyu*. MicroRNA-29b-3p inhibits the migration and invasion of gastric cancer cells by regulating the autophagy-associated protein maz[J]. OncoTargets and Therapy, 2021, 14: 3239-3249.
2020：
Feng Xueke, Liu Zhen, Jia Xiaoqiang, Lu Wenyu*. Distribution of bacterial communities in petroleum-contaminated soils from the dagang oilfield, China[J]. Transactions of Tianjin University, 2020, 26(1): 22-32.
Li Dashuai, Wu Yufen, Wei Panpan, Gao Xiao, Li Man, Zhang Chuanbo, Zhou Zhijiang, Lu Wenyu*. Metabolic engineering of Yarrowia lipolytica for heterologous oleanolic acid production[J]. Chemical Engineering Science, 2020, 218: 1-7.
Nan Weihua, Zhao Fanglong, Zhang Chuanbo, Ju Haiyan, Lu Wenyu*. Promotion of compound K production in Saccharomyces cerevisiae by glycerol[J]. Microbial Cell Factories, 2020, 19(1): 1-7.
Zhang Chuanbo, Li Man, Zhao Guang-Rong, Lu Wenyu*. Harnessing yeast peroxisomes and cytosol acetyl-coa for sesquiterpene alpha-humulene production[J]. Journal of Agricultural and Food Chemistry, 2020, 68(5): 1382-1389.
2019：
Zhao Fanglong, Zhang Chuanbo, Nan Weihua, Lu Wenyu*. An integrated bioprocess for fermentative production of protopanaxadiol by recycling ethanol waste during down-stream extraction process[J]. Journal of Cleaner Production, 2019, 234: 1-8.
Zhang Chuanbo, Ju Haiyan, Lu Chun Zhe, Zhao Fanglong, Liu Jingjing, Guo Xiaoyan, Wu Yufen, Zhao Guang Rong, Lu Wenyu*. High-titer production of 13R-manoyl oxide in metabolically engineered Saccharomyces cerevisiae[J]. Microbial cell factories, 2019, 18(1): 73-81.
Wu Yufen, Xu Shuo, Gao Xiao, Li Man, Li Dashuai, Lu Wenyu*. Enhanced protopanaxadiol production from xylose by engineered Yarrowia lipolytica[J]. Microbial cell factories, 2019, 18(1): 83-94.
Tan Jinxiu, Yang Xiaona, Lu Wenyu*. Research of 1,3-dihydroxyacetone production by overexpressing glycerol transporter and glycerol dehydrogenase[J]. Transactions of Tianjin University, 2019, 25(5): 1-10.
Liu Zhen, Wang Yiting, Jia Xiaoqiang, Lu Wenyu*. Isolation of secondary metabolites with antimicrobial activities from Bacillus amyloliquefaciens LWYZ003[J]. Transactions of Tianjin University, 2019, 25(01): 38-44.
Liu Jingjing, Zhang Chuanbo, Lu Wenyu*. Biosynthesis of long-chain ω-hydroxy fatty acids by engineered Saccharomyces cerevisiae[J]. Journal of agricultural and food chemistry, 2019, 67(16): 4545-4552.
Guo Xiaoyan, Liu Jingjing, Zhang Chuanbo, Zhao Fanglong, Lu Wenyu*. Stepwise increase in the production of 13R-manoyl oxide through metabolic engineering of Saccharomyces cerevisiae[J]. Biochemical Engineering Journal, 2019, 144: 73-80.
Zhao Fanglong, Bai Peng, Nan Weihua, Li Dashuai, Zhang Chuanbo, Chunzhe Lu, Haishan Qi, Wenyu Lu*. A modular engineering strategy for high‐level production of protopanaxadiol from ethanol by Saccharomyces cerevisiae[J]. AIChE Journal, 2019, 65(3): 866-874.
Li Dashuai, Wu Yufen, Zhang Chuanbo, Sun Jie, Zhou Zhijiang, Lu Wenyu*. Production of triterpene ginsenoside compound K in the nonconventional yeast Yarrowia lipolytica[J]. Journal of agricultural and food chemistry, 2019, 67(9): 2581–2588.
Jia Dan, Xu Shuo, Sun Jie, Zhang Chuanbo, Li Dashuai, Lu Wenyu*. Yarrowia lipolytica construction for heterologous synthesis of α-santalene and fermentation optimization[J]. Applied microbiology and biotechnology, 2019, 103(8): 3511-3520.
Zhang Chuanbo, Li Man, Zhao Guang-Rong, Lu Wenyu*. Alpha-Terpineol production from an engineered Saccharomyces cerevisiae cell factory[J]. Microbial cell factories, 2019, 18(1): 160-168.
2018：
Zhang Chuanbo, Liu Jingjing, Zhao Fanglong, Lu Chunzhe, Zhao Guang-Rong Lu Wenyu*. Production of sesquiterpenoid zerumbone from metabolic engineered Saccharomyces cerevisiae[J]. Metabolic Engineering, 2018, 49: 28-35.
Zhang Yaguang, Jia Dan, Sun Wanqi, Yang Xue, Zhang Chuanbo, Zhao Fanglong, Lu Wenyu*. Semicontinuous sophorolipid fermentation using a novel bioreactor with dual ventilation pipes and dual sieve-plates coupled with a novel separation system[J]. Microbial biotechnology, 2018, 11(3): 455-464.
Guo Xiaoyan, Sun Jie, Li Dashuai, Lu Wenyu*. Heterologous biosynthesis of (+)-nootkatone in unconventional yeast Yarrowia lipolytica[J]. Biochemical Engineering Journal, 2018, 137: 125-131.
Gao Xiao, Caiyin Qinggele, Zhao Fanglong, Wu Yufen, Lu Wenyu*. Engineering Saccharomyces cerevisiae for enhanced production of protopanaxadiol with cofermentation of glucose and xylose[J]. Journal of agricultural and food chemistry, 2018, 66(45): 12009–12016.
Liu Ting, Zhang Chuanbo, Lu Wenyu*. Heterologous production of levopimaric acid in Saccharomyces cerevisiae[J]. Microbial cell factories, 2018, 17(1): 114-123.
Sun Jie, Zhang Chuanbo, Nan Weihua, Li Dashuai, Ke Di, Lu Wenyu*. Glycerol improves heterologous biosynthesis of betulinic acid in engineered Yarrowia lipolytica[J]. Chemical Engineering Science, 2018, 196(82-90).
Ke Di, Caiyin Qinggele, Zhao Fanglong, Liu Ting, Lu Wenyu*. Heterologous biosynthesis of triterpenoid ambrein in engineered Escherichia coli[J]. Biotechnology letters, 2018, 40(2): 399-404.
Lu Chunzhe, Zhang Chuanbo, Zhao Fanglong, Li Dashuai, Lu Wenyu*. Biosynthesis of ursolic acid and oleanolic acid in Saccharomyces cerevisiae[J]. AIChE Journal, 2018, 64(11): 3794-3802.
Zhang Chuanbo, Ke Di, Duan Yuejiao, Lu Wenyu*. The combinatorial biosynthesis of “unnatural” products with polyketides[J]. Transactions of Tianjin University, 2018, 24(6): 501-512.
2017：
Zhao Fanglong, Du Yanhui, Bai Peng, Liu Jingjing, Lu Wenyu*, Yuan Yingjin. Enhancing Saccharomyces cerevisiae reactive oxygen species and ethanol stress tolerance for high-level production of protopanoxadiol[J]. Bioresource Technology, 2017, 227: 308-316.
Lu Chunzhe, Yin Jing, Zhang Chuanbo, Lu Wenyu*. Fed-batch fermentation for spinosad production in an improved reactor[J]. Transactions of Tianjin University, 2017, 23(6): 530-537.
Liu Ting, Zhang Xiangmei, Zhao Fanglong, Lu Wenyu*. Molecular simulation and catalytic active sites identification of dammarenediol-II synthase[J]. Journal of Beijing Institute of Technology, 2017, 26(04): 563-570.
Jia Xiaoqiang, Qi Lin, Zhang Yaguang, Yang Xue, Wang Hongna, Zhao Fanglong, Lu Wenyu*. Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production[J]. Chinese Journal of Chemical Engineering, 2017, 25(06): 732-740.
Chunzhe Lu, Jing Yin, Fanglong Zhao, Feng Li, Wenyu Lu*. Metabolomics analysis of the effect of dissolved oxygen on spinosad production by Saccharopolyspora spinosa[J]. Antonie van Leeuwenhoek, 2017, 110(5): 677-685.
2016：
Zhao Fanglong, Bai Peng, Liu Ting, Li Dashuai, Zhang Xiangmei, Lu Wenyu*, Yuan Yingjin. Optimization of a cytochrome P450 oxidation system for enhancing protopanaxadiol production in Saccharomyces cerevisiae[J]. Biotechnology and bioengineering, 2016, 113(8): 1787-1795.
Li Dashuai, Zhang Qiang, Zhou Zhijiang, Zhao Fanglong, Lu Wenyu*. Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli[J]. Biotechnology letters, 2016, 38(4): 603-609.
2015：
Zhang Chuanbo, Xue Chaoyou, Shen Yueqi, Lu Wenyu*. Selection of reference genes in Saccharopolyspora spinosa for real-time PCR[J]. Transactions of Tianjin University, 2015, 21(5): 461-467.
Lin, Fujian, Guo, Xiaoyan, Lu Wenyu*. Efficient biotransformation of ginsenoside Rb-1 to Rd by isolated Aspergillus versicolor, excreting beta-glucosidase in the spore production phase of solid culture[J]. Antonie van Leeuwenhoek, 2015, 108(5): 1117-1127.
Zhao Fanglong, Zhang Chuanbo, Yin Jing, Shen Yueqi, Lu Wenyu*. Coupling of spinosad fermentation and separation process via two-step macroporous resin adsorption method[J]. Applied biochemistry and biotechnology, 2015, 176(8): 2144-2156.
Hu Cheng, Lu Wenyu*. Insight into yeast: A study model of lipid metabolism and terpenoid biosynthesis[J]. Biotechnology and applied biochemistry, 2015, 62(3): 323-328.
2014：
Wang Xiaoyang, Zhang Chuanbo, Wang Meiling, Lu Wenyu*. Genome-scale metabolic network reconstruction of Saccharopolyspora spinosa for spinosad production improvement[J]. Microbial cell factories, 2014, 13(1): 41-47.
Zhang Xiangmei, Xue Chaoyou, Zhao Fanglong, Li Dashuai, Yin Jing, Zhang Chuanbo, Caiyin Qinggele, Lu Wenyu*. Suitable extracellular oxidoreduction potential inhibit rex regulation and effect central carbon and energy metabolism in Saccharopolyspora spinosa[J]. Microbial cell factories, 2014, 13(1): 98-108.
Wu Xinsen, Wang Xiaoyang, Lu Wenyu*. Genome-scale reconstruction of a metabolic network for Gluconobacter oxydans 621H[J]. BioSystems, 2014, 117: 10-14.
2013：
Zhao Fanglong, Xue Chaoyou, Wang Meiling, Wang Xiaoyang, Lu Wenyu*. A comparative metabolomics analysis of Saccharopolyspora spinosa WT, WH124, and Lu104 revealed metabolic mechanisms correlated with increases in spinosad yield[J]. Bioscience, Biotechnology, and Biochemistry, 2013, 77(8): 1661-1668.
Xue Chaoyou, Zhang Xiangmei, Yu Zhirui, Zhao Fanglong, Wang Meiling, Lu Wenyu*. Up-regulated spinosad pathway coupling with the increased concentration of acetyl-CoA and malonyl-CoA contributed to the increase of spinosad in the presence of exogenous fatty acid[J]. Biochemical Engineering Journal, 2013, 81(Complete): 47-53.
Xue Chaoyou, Duan Yuejiao, Zhao Fanglong, Lu Wenyu*. Stepwise increase of spinosad production in Saccharopolyspora spinosa by metabolic engineering[J]. Biochemical Engineering Journal, 2013, 72: 90–95.
2012：
Zhu Lingqing, Yang Xue, Xue Chaoyou, Chen Yu, Qu Liang, Lu Wenyu*. Enhanced rhamnolipids production by Pseudomonas aeruginosa based on a pH stage-controlled fed-batch fermentation process[J]. Bioresource Technology, 2012, 117: 208-213.
Yang Xue, Zhu Lingqing, Xue Chaoyou, Chen Yu, Qu Liang, Lu Wenyu*. Recovery of purified lactonic sophorolipids by spontaneous crystallization during the fermentation of sugarcane molasses with Candida albicans O-13-1[J]. Enzyme and Microbial Technology, 2012, 51(6): 348-353.
Wu Xinsen, Xia Zhendong, Yang Xiaona, Xue Chaoyou, Lu Wenyu*. Molecular simulation of pyrroloquinoline quinine-dependent glycerol dehydrogenase in Gluconobacter oxydans[J]. Molecular Simulation, 2012, 38(12): 1010-1014.
授权发明专利如下：
1) 卢文玉, 尹静, 张传波. 生物反应器[P]. 中国实用新型专利, 授权号: ZL201420684713.X
2) 卢文玉, 王晓阳, 张传波. 刺糖多孢菌基因组尺度代谢网络模型及构建方法及应用[P]. 中国发明专利, 授权号: ZL201310756418.0
3) 卢文玉, 王美玲, 赵方龙, 尹静. 一种多杀菌素的发酵方法[P]. 中国发明专利, 授权号: ZL201310756416.1
4) 卢文玉, 薛朝友, 张香梅. 能提高多杀菌素产量的基因工程菌及构建方法及应用[P]. 中国发明专利, 授权号: ZL201310756049.5
5) 卢文玉, 赵方龙. 能提高达玛烯二醇转化效率的融合蛋白质及构建方法及应用[P]. 中国发明专利, 授权号: ZL201410734624.6
6) 卢文玉, 赵方龙.能提高达玛烯二醇转化效率的融合蛋白质及构建方法[P]. 中国发明专利, 授权号: ZL201410736994.3
7) 卢文玉, 赵方龙. 一种能提高达玛烯二醇转化效率的融合蛋白质及构建方法及应用[P]. 中国发明专利, 授权号: ZL201410735927.X
8) 卢文玉, 李大帅, 张强, 赵方龙. 合成达玛烯二醇的大肠杆菌基因工程菌株及构建方法[P]. 中国发明专利, 授权号: ZL201510672700.X
9) 卢文玉, 张亚光, 杨雪. 一种槐糖脂发酵生物分离系统及方法[P]. 中国发明专利, 授权号: ZL201610343815.9
10) 卢文玉, 林福建, 郭校燕. 一种转化人参皂苷Rb1生产Rd的曲霉及应用[P]. 中国发明专利, 授权号: ZL201510543267.x
11) 卢文玉, 可迪. 异源合成龙涎香醇的重组大肠杆菌及其构建方法[P]. 中国发明专利, 授权号: ZL201711111081.2
12) 卢文玉, 高晓. 利用木糖生产达玛烯二醇和原人参二醇的重组酿酒酵母菌及构建方法[P]. 中国发明专利, 授权号: ZL 201810781608.0
13) 卢文玉, 张传波, 陆春哲. 生产熊果酸和齐墩果酸的重组酵母菌及其构建方法和应用[P]. 中国发明专利, 授权号: ZL202010075904.6
14) 卢文玉, 鞠海燕, 刘婷, 张传波. 生产龙涎香醇的重组酿酒酵母菌及构建方法[P]. 中国发明专利, 授权号: ZL202010113440.3
15) 卢文玉, 张传波, 叶楠, 田锦平. 异源合成人参皂苷F2的重组酿酒酵母及其构建方法[P]. 中国发明专利, 授权号: ZL202111364221.3
16) 卢文玉, 张传波, 魏盼盼, 牌慧慧. 异源合成鼠尾草酸的重组酿酒酵母及构建方法[P]. 中国发明专利, 授权号: ZL 202111364217.7
17) 卢文玉, 张传波, 田锦平, 刘瑞霞. 代谢甘油生产人参皂苷CK的重组酿酒酵母菌及构建方法[P]. 中国发明专利, 授权号: ZL 202210519519.5
18) 卢文玉, 张传波, 鞠海燕. 生产毛喉素的重组酿酒酵母菌及构建方法[P]. 中国发明专利, 授权号: ZL202111364198.8