Title: Prefessor
Address:
Office Phone:
Email: yjyuan@tju.edu.cn
Dr. Yingjin Yuan is a professor affiliated with School of Chemical Engineering and Technology, Tianjin University. He was elected as an academician of the Chinese Academy of Sciences in 2021. He was also elected as IChemE Fellow in 2010. Dr. Yuan received all his academic degrees (BS, MS and PhD) from Tianjin University and was a senior visiting fellow at MIT. He was awarded the “National Science Fund for Distinguished Young Scholars” in 2004. Dr. Yuan was the academic leader of the Innovation Research Group of the National Natural Science Foundation of China, and the chief scientist of the National Key Basic Research Program (973 Program). He is the editor-in-chief of the Synthetic Biology Journal, and the director of Frontier Science Center for Synthetic Biology (Ministry of Education). Dr. Yuan has been working in the field of Biochemical Engineering, especially the development of yeast artificial chromosomes. He was awarded the “Hou Debang Chemical Science and Technology Achievement Award” in 2017. He was also awarded the “Distinguished College Teacher Prize (the Ministry of Education)” in 2007.
Dr. Yuan and his research group developed the PCRTag mapping (PoPM) strategy for efficient identification and the CRISPR-mediated method for repairing of unexpected bugs during chromosome synthesis. With the developed technologies in bug mapping and debugging, his group successfully synthesized two yeast artificial chromosomes, synV and syn X. It was noted that synV “perfectly” matches all designer sequences. The achievement was selected into the China's top 10 scientific advances in 2017. Dr. Yuan also endeavors to promote industrial applications of yeast artificial chromosomes, which include digital information storage and endowing yeast strains with advantages in increased production of valuable chemicals. He invented a precisely controlled SCRaMBLE (synthetic chromosome rearrangement and modification by LoxP-mediated evolution) system that can be used for directed genome evolution.
Selected Publications
1 Yi Wu#, Bingzhi Li#, Meng Zhao, Leslie A. Mitchell, Zexiong Xie, Qiuhui Lin, Xia Wang, Wenhai Xiao, Ying Wang, Xiao Zhou, Hong Liu, Xia Li, Mingzhu Ding, Duo Liu, Lu Zhang, Baoli Liu, Xiaole Wu, Feifei Li, Xiutao Dong, Bin Jia, Wenzheng Zhang, Guozhen Jiang, Yue Liu, Xue Bai, Tianqing Song, Yan Chen, Sijie Zhou, Ruiying Zhu, Feng Gao, Zheng Kuang, Xuya Wang, Michael Shen, Kun Yang, Giovanni Stracquadanio, Sarah M. Richardson, Yicong Lin, Lihui Wang, Roy Walker, Yisha Luo, Pingsheng Ma, Huanming Yang, Yizhi Cai, Junbiao Dai, Joel S. Bader, Jef D. Boeke, Yingjin Yuan*. Bug mapping and fitness testing of chemically synthesized chromosome X. Science, 355(6329)(2017):eaaf4706.
2 Zexiong Xie#, Bingzhi Li#, Leslie A. Mitchell, Yi Wu, Xin Qi, Zhu Jin, Bin Jia, Xia Wang, Boxuan Zeng, Huimin Liu, Xiaole Wu, Qi Feng, Wenzheng Zhang, Wei Liu, Mingzhu Ding, Xia Li, Guangrong Zhao, Jianjun Qiao, Jingsheng Cheng, Meng Zhao, Zheng Kuang, Xuya Wang, J. Andrew Martin, Giovanni Stracquadanio, Kun Yang, Xue Bai, Juan Zhao, Menglong Hu, Qiuhui Lin, Wenqian Zhang, Minghua Shen, Si Chen, Wan Su, Enxu Wang, Rui Guo, Fang Zhai, Xuejiao Guo, Haoxing Du, Jiaqing Zhu, Tianqing Song, Junjun Dai, Feifei Li, Guozhen Jiang, Shilei Han, Shiyang Liu, Zhichao Yu, Xiaona Yang, Ken Chen, Cheng Hu, Dashuai Li, Nan Jia, Yue Liu, Linting Wang, Su Wang, Xiaotong Wei, Meiqing Fu, Lanmeng Qu, Siyu Xin, Ting Liu, Kairen Tian, Xuenan Li, Jinhua Zhang, Lixiang Song, Jingui Liu, Jiafei Lv, Hang Xu, Ran Tao, Yan Wang, Tingting Zhang, Yexuan Deng, Yiran Wang, Ting Li, Guangxin Ye, Xiaoran Xu, Zhengbao Xia, Wei Zhang, Shilan Yang, Yilin Liu, Wenqi Ding, Zhenning Liu, Junqi Zhu, Ningzhi Liu, Roy Walker, Yisha Luo, Yun Wang, Yue Shen, Huanming Yang, Yizhi Cai, Pingsheng Ma, Chunting Zhang, Joel S. Bader, Jef D. Boeke, Yingjin Yuan*. “Perfect” designer chromosome V and behavior of a ring derivative. Science, 355(6329)(2017):eaaf4704.
3 Bin Jia#, Yi Wu#, Bingzhi Li#, Leslie A. Mitchell, Hong Liu, Shuo Pan, Juan Wang, Haoran Zhang, Nan Jia, Bo Li, Michael Shen, Zexiong Xie, Duo Liu, Yingxiu Cao, Xia Li, Xiao Zhou, Hao Qi, Jef D. Boeke, Yingjin Yuan*. Precise control of SCRaMbLE in synthetic haploid and diploid yeast. Nature Communications, 9(2018):1933.
4 Juan Wang#, Zexiong Xie#, Yuan Ma, Xiangrong Chen, Yaoqing Huang, Bo He, Bin Jia, Bingzhi Li, Yingjin Yuan*. Ring synthetic chromosome V SCRaMbLE. Nature Communications, 9(2018):3783.
5 Weigang Chen#, Mingzhe Han#, Jianting Zhou#, Qi Ge, Panpan Wang, Xinchen Zhang, Siyu Zhu, Lifu Song, Yingjin Yuan*. An artificial chromosome for data storage. National Science Review, 8(2021):nwab028.
6 Qiuhui Lin#, Bin Jia#, Leslie A. Mitchell, Jingchuan Luo, Kun Yang, Karen I. Zeller, Wenqian Zhang, Zhuwei Xu, Giovanni Stracquadanio, Joel S. Bader, Jef D. Boeke, Yingjin Yuan*. RADOM, an effici ent in vivo method for assembling designed DNA fragments up to 10 kb long in Saccharomyces cerevisiae. ACS Synthetic Biology, 4(3)(2015):213-220.
7 Duo Liu, Hong Liu, Bingzhi Li, Hao Qi, Bin Jia, Xiao Zhou, Haoxing Du, Wei Zhang, Yingjin Yuan*. Multigene pathway engineering with regulatory linkers (M-PERL). ACS Synthetic Biology, 5(12)(2016):1535-1545
8 Jinlai Zhang#, Yingxiu Cao#, Yangzi Peng, Congcong Jin, Qiuyan Bai, Ruosi Zhang, Duo Liu, Yingjin Yuan*. High production of fatty alcohols in Yarrowia lipolytica by coordination with glycolysis. SCIENCE CHINA Chemistry, 62(8)(2019):1007-1016.
9 Yunxiang Li, Yi Wu, Lu Ma, Zhou Guo, Wenhai Xiao, Yingjin Yuan*. Loss of heterozygosity by SCRaMbLEing. SCIENCE CHINA Life Sciences, 62(3)(2019):381-393.
10 Yingxiu Cao, Wenhai Xiao, Duo Liu, Jinlai Zhang, Mingzhu Ding, Yingjin Yuan*. Biosynthesis of odd-chain fatty alcohols in Escherichia coli. Metabolic Engineering, 29(2015):113-123.
11 Yingxiu Cao#, Wenhai Xiao#, Jinlai Zhang, Zexiong Xie, Mingzhu Ding, Yingjin Yuan*. Heterologous biosynthesis and manipulation of alkanes in Escherichia coli. Metabolic Engineering, 38(2016):19-28.
12 Zexiong Xie, Duo Liu, Bingzhi Li, Meng Zhao, Boxuan Zeng, Yi Wu, Yue Shen, Tao Lin, Ping Yang, Junbiao Dai, Yizhi Cai, Huanming Yang, Yingjin Yuan*. Design and chemical synthesis of eukaryotic chromosomes. Chemical Society Reviews, 46(23)(2017):7191-7207.
13 Yue Liu, Mingzhu Ding, Wei Ling, Yun Yang, Xiao Zhou, Bingzhi Li, Tao Chen, Yong Nie, Miaoxiao Wang, Boxuan Zeng, Xia Li, Hong Liu, Baode Sun, Heming Xu, Jiamei Zhang, Yi Jiao, Yanan Hou, Hui Yang, Sijia Xiao, Qucheng Lin, Xinzi He, Wenjie Liao, Zeqi Jin, Yufei Xie, Bofeng Zhang, Tianyu Li, Xi Lu, Jiabei Li, Fan Zhang, Xiaolei Wu, Hao Song*, Yingjin Yuan*. A three-species microbial consortium for power generation. Energy & Environmental Science, 10(7)(2017):1600-1609.